Fig. 2

Comparison of neurograms recorded with hook and cuff electrodes. Baseline activity from the cervical vagus nerve was recorded for 10 min from Balb/c mice with either a hook (n = 72) or a cuff (n = 25) electrode. a Representative recording of the neural signals by three hook electrode in a 10 min window, b) The inset from (a) is expanded as a 2 s window, c) The inset from (b) is expanded as a 100 millisecond window with CAP’s indicated by the asterisk. d Representative recording of the neural signals recorded by the cuff electrode in a 10 min window, e) The inset from (d) is expanded as a 2 s window, and f) The inset from (e) is expanded as a 100 millisecond window with CAP’s indicated by the asterisk. g Addition of KCl (4 mM) indicated by the red line directly to the cervical vagus nerve causes depolarization and CAP’s to fire (indicated by asterisk). h) Pretreatment with 2% lidocaine inhibits the depolarization and subsequent CAP firing induced by the addition of KCl (4 mM) indicated by the red line