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Table 1 Summary of EEG DBS studies and their principal results. Subjects number were given only for those who had direct stimulation or ON/OFF DBS protocol

From: Electroencephalographic read-outs of the modulation of cortical network activity by deep brain stimulation

Study Subjects DBS target Protocol DBS effect
Direct effect
  Ashby et al. (2001) 6 PD STN   CEPs at 3, 5 and 8 ms
  Baker et al. (2002) 10 PD, 4 Epi STN   CEPs from 1 to 400 ms
  MacKinnon et al. (2005) 11 PD STN Electrical skin stimulation CEP at 23 ms
 Zumsteg (2006) 9 Epi Thal   CEPs between 20 and 320 ms
 Zumsteg (2006) 6 Epi Thal   CEPs at 24, 34 and 70 ms
  Tisch et al. (2008) 6 Pri Gen Dyst GP   CEP at 26.6 ms
  Eusebio et al. (2009) 16 PD STN   CEP at 21 ms
 Walker (2012a) 5 PD STN   CEPs at 1, 5.7 and 22.2 ms
 Walker (2012b) 5 Ess Trem Thal   CEPs at 0.9, 5.6 and 13.9 ms
ON/OFF designs
  Gerschlager et al. (1999) 10 PD, 10 HC STN Go/NoGo Increased contingent negative variation amplitude
  Pierantozzi et al. (1999) 6 PD STN, GPi Electrical skin stimulation Increased frontal N30 amplitude
  Gerschlager et al. (2001) 8 PD STN Auditory oddball task No effect on P300 latency
  Priori et al. (2001) 9 PD STN Electrical skin stimulation Reduced N20 amplitude
Passive visual task Reduced P100 amplitude
  Devos et al. (2002) 6 PD GPi Wrist flexion movement Increased contralateral premovement/movement ERD
  Devos et al. (2003) 10 PD STN Wrist flexion movement Increased beta ERS
  Devos et al. (2004) 10 PD, 10 HC STN Wrist flexion movement Reduced ERD spread and increased ERD amplitude
  Insola et al. (2005) 1 PD STN Electrical skin stimulation Increased N20 and N30 amplitudes
  Silberstein et al. (2005) 16 PD STN Resting state Reduced beta cortical coupling
  Jech et al. (2006) 11 PD STN Resting state Reduced alpha power
Passive visual task Reduced N70/P100
  Kovacs et al. (2008) 23 PD, 11 HC STN Auditory oddball task P300 amplitude correlated to DBS voltage
  Conte et al. (2010) 13 PD, 13 HC STN Somatosensory temporal discrimination task Reduced parietal SEP amplitude
  Klostermann et al. (2010) 10 PD STN Choice response task Reduced lateralized readiness potentials
Oddball task
  Cavanagh et al. (2011) 14 PD STN Decision task Inversed theta power relation to RT
  Swann et al. (2011) 15 PD, 15 HC STN Stop signal task Increased right frontal beta power
  Broadway et al. (2012) 12 TRD SCC Resting state Increased frontal theta cordance
 Selzler (2013) 10 PD, 20 HC STN Working memory task Reduced N200 amplitude and increased N200 latency
  Figee et al. (2013) 13 OCD NAc Symptom provocation task Reduced low frequency ERS
  Smolders et al. (2013) 8 OCD NAc Resting state Reduced frontal theta phase stability
  Quraan et al. (2014) 12 TRD, 15 HC SCC Resting state Frontal theta and parietal alpha asymmetry dependent on clinical response
 Hilimire (2015) 7 TRD SCC Emotional self referential task Reduced P1 and P3 amplitudes
  Gulberti et al. (2015a) 12 PD, 12 HC STN Rhythmic auditory stimulation Reduced P1/N1 amplitude
  Gulberti et al. (2015b) 12 PD, 12 HC STN Rhythmic auditory stimulation
Resting state
Normalized beta modulation
Reduced beta power
  Sun et al. (2015) 20 TRD SCC Working memory task Reduced frontal gamma and beta power and increased theta-gamma coupling
 Kibleur (2016) 12 OCD STN Stop signal task Reduced P300 amplitude and increased P300 latency and reduced basal ganglia to right frontal cx connection strength
 Kibleur (2017) 5 TRD SCC Emotional Stroop task Reduced N170 amplitude and reduced temporal pole to visual ventral cx connection strength
  1. PD Parkinson’s Disease, Epi epilepsy, Pri Gen Dyst primary generalized dystonia, Ess Trem Essential Tremor, HC healthy control, TRD treatment resistant depression, OCD obsessive compulsive disorder, STN subthalamic nucleus, Thal thalamus, GP globus pallidus, GPi globus pallidus internus, NAc nucleus accumbens, SCC subcallosal cingulate cortex, SCEP subcortical-cortical evoked potential, ERS event related synchronization, ERD event related desynchronization, SEP somato-sensory evoked potential, RT reaction time, cx cortex