Skip to main content

Table 2 Peripheral pathways involved in pancreatic secretion and benefit of modulating them for diabetes management

From: Review of the role of the nervous system in glucose homoeostasis and future perspectives towards the management of diabetes

Peripheral pathway NT Pancreatic receptor Impact on endocrine pancreas Impact on glucose homeostasis Opportunities for diabetes management
Parasympathetic ACh Muscarinic receptors (m3AChR) insulin glucagon β-cell number postprandial glucose levels Tighter control of glucose levels and preparation of the body to meals
  VIP, PACAP, GRP VIP, PACAP, GRP hormonal secretion (less studied) - -
Sympathetic   β-cells α-adrenoreceptors Inhibit basal & glucose-dependent insulin secretion glucose levels Reduction of hypoglycemia
  NE β-cells β-adrenoreceptors insulin secretion glucose levels Reduction of hyperglycemia
   α-cells β2-adrenoreceptors glucagon insulin glucose levels Control of glucose homeostasis
  Galanin & NPY Specific receptors Great range of responses - -
  1. This table shows the peripheral pathways that are most involved in the pancreatic secretion and the neurotransmitter (NT) involved in each of them. The effect of increasing their basal tone on glucose homeostasis and the potential benefits of modulating their firing pattern for diabetes management are summarised as well