Skip to main content
Fig. 1 | Bioelectronic Medicine

Fig. 1

From: Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches

Fig. 1

Null effect of uridine on basal synaptic transmission. a Left, representative input-output (I-O) experiments for uridine (300 μM) and control; with the amplitude of the fiber volley (FV) as the independent variable and the slope of the fEPSP as the dependent variable. Right, sample overlaid traces from single I-O experiments. Electrical stimulation artifacts have been removed and are marked by arrowheads. b Plots of I-O responses (mean ± SEM) indicate that basal synaptic transmission is not affected by any of the uridine concentrations tested. c Representative experiment showing that the fEPSP slope remains unchanged when uridine (300 μM) is added to the brain slice placed in the recording chamber. d Normalized fEPSP slope (mean ± SEM) showing that uridine (3 μM, 30 μM, and 300 μM) does not cause changes in field synaptic potentials, when measured 30 min post-application

Back to article page