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Fig. 4 | Bioelectronic Medicine

Fig. 4

From: Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches

Fig. 4

Uridine decreases NMDAR-mediated synaptic responses. a Representative single theta-burst stimulation (TBS) event during LTP induction. Shaded areas indicate the total depolarization measured. b Mean total depolarization during TBS tetanus, which is highly mediated by NMDARs, is significantly lower in the presence of uridine (300 μM); * P < 0.05 (MWU test). Numbers within bars indicate number of brain slices per group. c Plot shows mean fEPSP amplitudes of pharmacologically isolated NMDAR-mediated fEPSPs in several conditions: (i) baseline, no uridine (ii) uridine (300 μM), and (iii) uridine (300 μM) + D-AP5 (100 μM). Accompanying sample traces from each condition are shown in the insets. d Cumulative probability plots show that uridine (300 μM) significantly decrease NMDAR–mediated fEPSPs amplitudes, which are essentially eliminated in the presence of the NMDAR antagonist D-AP5

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