Fig. 8
From: Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action
Cortical and Sub-cortical Pain Processing. Sensory-discriminative pain processing with thalamus, SI, SII and posterior IC, with sensory discriminative pain relayed through the ventroposterior-lateral and ventroposterior-medial thalamic nuclei and is also termed the neospinothalamic pathway. Affective-emotional pain processing with dorsal ACC and Anterior IC while affective sensory information to the AEN is thought to be relayed through the medio-dorsal thalamus, also termed the paleospinothalamic pathway. PFC (Prefrontal Cortex), OFC (orbitofrontal cortex) SI (Primary Somatosensory Cortex) SII (Secondary Somatosensory Cortex) dACC (Dorsal Anterior Cingulate Cortex) Amy (Amygdala), AI (Anterior Insula), RI (Rostral Insula) dPI (Dorsoposterior Insula), PAG (Periaqueductal Gray)