Fig. 1

Recording Neural Events in Acute Hyper and Hypoglycemia. a Mice are anesthetized with isoflurane, the nerve is fitted with a bipolar, cuff electrode from Cortec and activity is recorded using a Plexon acquisition system. After 30 min’ baseline recording, mice received 6 mg/kg insulin, 2 g/kg glucose, or saline, and were recorded for an additional 30 min. b Blood glucose was measured via tail nick with glucometer throughout the recording. Blood glucose dropped significantly in mice that received insulin within 10 min. Blood glucose rose significantly in mice that received glucose