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Fig. 1 | Bioelectronic Medicine

Fig. 1

From: Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs

Fig. 1

a A schematic diagram of the primary and secondary lymph organs in the rat, along with potential paths of the lymphatic ducts and associated connecting nerves (green- thyroid glands, purple- liver, red- spleen, blue- lymphatic duct, white- lymph nodes and lymphatic ducts, yellow- lymph associated nerves). b A timeline of the experimental procedure for lymph node nerve stimulation and subsequent tissue excision and analysis. c Normalized concentration of norepinephrine and epinephrine in excised tissues with (Stim) and without (sham control; CTRL) electrical sciatic nerve stimulation (see materials and methods for stimulation details), or with electrical stimulation following local lidocaine administration (+LC). N = 7. One way ANOVA with multiple comparison analysis * = p ≤ 0.05, ** = p ≤ 0.005,*** = p ≤ 0.0005; Electrical stimulation parameters: 0.5 mA, 20 Hz, pulse length 50 msec

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