Fig. 3

Mean baseline and changes in metabolic network activity of PDTP/PDRP with deep brain stimulation in PD. a/b. Baseline activity of both networks was elevated in the Vim STN and the STN DBS groups relative to normal controls. PDTP activity was comparable between the two DBS treatment groups although PDRP activity was higher in the STN than in the Vim DBS group (p < 0.01). c/d. STN DBS reduced activity of both networks compared to the test-retest PD group (p < 0.05) while Vim DBS changed PDTP activity (p < 0.001) but did not alter PDRP activity. PDTP activity was suppressed more by Vim DBS than by STN DBS (p < 0.05). [Data are presented as mean and standard error; Reprinted from Neuroimage 54:1244–1253. Mure H, Hirano S, Tang CC, Isaias IU, Antonini A, Ma Y, Dhawan V, Eidelberg D. Parkinson’s disease tremor-related metabolic network: characterization, progression, and treatment effects. Copyright (2011), with permission from Elsevier]