Fig. 4

Modulation of specific connections in the motor network by effective STN DBS. Functional connectivity increased between motor thalamus and motor cortex as a function of DBS impact on motor STN. Connectivity decreased between the motor STN and motor striatum or motor external globus pallidus (GPe) and between the motor striatum and cerebellum [**p < 0.005, *p < 0.05 corrected for multiple comparisons using the network-based statistical analysis; Horn A, Wenzel G, Irmen F, Huebl J, Li N, Neumann WJ, Krause P, Bohner G, Scheel M, Kuhn AA. Deep brain stimulation induced normalization of the human functional connectome in Parkinson’s disease. Brain 2019; 142:3129–3143, by permission of Oxford University Press]