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Fig. 4 | Bioelectronic Medicine

Fig. 4

From: The impact of closed-loop intracortical stimulation on neural activity in brain-injured, anesthetized animals

Fig. 4

Effect of the stimulation on the firing rate: ADS vs CTR. A) 20-s raster plots of the activity recorded in RFA in a representative Activity-Dependent Stimulation (ADS) experiment: Pre Stim phase - PreS (A1) and Post Stim phase - PoS (A2). B) 20-s raster plot of the activity recorded in RFA in a representative Control (CTR) experiment: Post Stim phase - PoS (B). C) Box plot of the Mean Firing Rate (MFR, spikes/s) of RFA for the entire dataset of CTR and ADS experiments. D) A 20-s raster plot of the activity recorded in S1 in a representative Activity-Dependent Stimulation (ADS) experiment: Pre Stim phase - PreS (D1) and Post Stim phase - PoS (D2). E) A 20-s raster plot of the activity recorded in S1 in a representative Control (CTR) experiment: Post Stim phase - PoS (E). F) Box plot of the Mean Firing Rate (MFR, spikes/s) of S1 for the entire dataset of CTR and ADS experiments. For each box plot (C- F), the central black dot indicates the median, the box limits indicate the 25th and 75th percentiles. Whiskers represent the 5th and the 95th percentiles. *p < 8·10− 3, **p < 8·10− 5 Wilcoxon signed rank test; #p < 8·10− 3 Wilcoxon rank-sum test. Color code as in Fig. 1C

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