Fig. 1

Brain regions with overlapping increases in [¹¹C]PBR28 and [¹⁸F]FDG uptakes during endotoxemia. A Dual tracer conjunction increases in metabolism and microglial activation (TSPO binding). Brain coronal sections of statistically significant clusters (color bar represents t-value height, extent threshold T = 2.85), overlaid onto MRI atlas for visualization. Statistically significant clusters (P < 0.005) show overlapping regions of increased uptake of [¹¹C]PBR28 and [¹⁸F]FDG in the hippocampus, the thalamus, and the hypothalamus in LPS administered (n = 6) vs saline administered (n = 6) mice (see Table 1 for stereotaxic coordinates). B Post-hoc analysis for the same statistically significant increases in metabolic activity [¹⁸F]FDG and microglial activation [¹¹C]PBR28 (TSPO binding) in saline (n = 6) and LPS (n = 6) mice. **P = 0.002, **P = 0.004 (hippocampus - [¹¹C]PBR28). See Methods for details