Fig. 2

Brain regions with individual increases in [¹¹C]PBR28 and [¹⁸F]FDG uptake during endotoxemia. A Increased [¹⁸F]FDG uptake in the hippocampus, the thalamus, the hypothalamus, and the cerebellum shown in coronal sections in LPS administered (n = 6) vs saline administered (n = 6) mice (see Table 1 for specific stereotaxic coordinates). SPM clusters (color bar represents t-value height, cutoff threshold T = 3.55) overlaid onto MRI atlas for visualization. Statistically significant clusters (P < 0.001). B Post-hoc analysis of [¹⁸F]FDG tracer uptake in the same groups (saline, n = 6 and LPS, n = 6) of mice. **P = 0.002. C Increased [¹¹C]PBR28 metabolic activity in the hippocampus, the thalamus, the hypothalamus, and the brainstem shown in coronal sections in LPS administered (n = 6) vs saline administered (n = 6) mice (see Table 1 for stereotaxic coordinates). SPM clusters (color bar represents t-value height, cutoff threshold T = 3.55). Statistically significant clusters (P < 0.001) overlaid onto MRI atlas for visualization. D Post-hoc analysis of [¹¹C]PBR28 uptake in the same groups (saline, n = 6 and LPS, n = 6) of mice. **P = 0.002, **P = 0.004 (hippocampus). See Methods for details