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Table 1 Specific brain regions with significant [18F]FDG and [11C]PBR28 uptake increases*

From: A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia

Radiotracer/Brain region

Brain coordinates**

Relative radiotracer

uptake (controls)

(mean ± SD)

Relative radiotracer uptake (LPS) (mean ± SD)

X (mm)

Y (mm)

Z (mm)

Dual [18F]FDG and [11C]PBR28 uptake

Paraventricular hypothalamus anterior parvicellular

0.2

−0.5

−4.5

[18F]FDG = 2.06 ± 0.11

[11C]PBR28 = 1.56 ± 0.11

[18F]FDG = 2.36 ± 0.11

[11C]PBR28 = 2.07 ± 0.14

CA1 Hippocampus pyramidal cell layer

−3.3

− 3.5

− 4.1

[18F]FDG = 2.02 ± 0.03

[11C]PBR28 = 1.87 ± 0.15

[18F]FDG = 2.28 ± 0.10

[11C]PBR28 = 2.23 ± 0.11

CA1 Hippocampus pyramidal cell layer

3.4

−3.3

−4.0

LP Thalamic nucleus laterocaudal

−1.9

− 2.8

− 2.6

[18F]FDG = 2.07 ± 0.08

[11C]PBR28 = 1.45 ± 0.05

[18F]FDG = 2.34 ± 0.06

[11C]PBR28 = 1.75 ± 0.11

[18F]FDG uptake

Glomerular layer olfactory

0.0

0.0

−0.2

4.4

5.2

5.5

−2.9

− 3.4

− 2.8

2.14 ± 0.10

2.71 ± 0.26

Periaqueductal grey

−2.3

− 2.8

−2.9

2.12 ± 0.07

2.50 ± 0.21

CA1 Pyramidal layer hippocampus

3.3

−3.0

−3.4

1.99 ± 0.03

2.28 ± 0.13

Red nucleus parvicell part

− 0.6

−3.2

− 3.8

2.29 ± 0.21

2.83 ± 0.14

Posterior thalamic nucleus

−1.0

−3.4

− 3.4

2.09 ± 0.08

2.37 ± 0.07

[11C]PBR28 uptake

Tuberal region lateral hypothalamus

0.9

−0.9

−5.2

1.56 ± 0.11

2.07 ± 0.14

Medial amygdalar nucleus posterodorsal

1.8

−1.4

−5.2

1.85 ± 0.10

2.34 ± 0.10

Parasubthalamic nucleus

1.3

−2.1

−5.0

1.45 ± 0.05

1.75 ± 0.11

Caudomedial entorhinal

3.5

3.2

−5.1

− 5.1

−4.1

− 4.6

1.87 ± 0.15

2.23 ± 0.11

  1. *Increased tracer uptake was identified using statistical parametric mapping (SPM5) with P < 0.005 in the conjunction analysis and P < 0.001 in the individual tracer uptake analysis (with an extent threshold of t = 500 voxels), comparing saline administered mice (n = 6) vs LPS administered mice (n = 6)
  2. **According to (Paxinos & Franklin, 2019), X (Mediolateral), Y (Anteroposterior), Z (Dorsoventral)