Radiotracer/Brain region | Brain coordinates** | Relative radiotracer uptake (controls) (mean ± SD) | Relative radiotracer uptake (LPS) (mean ± SD) | ||
---|---|---|---|---|---|
X (mm) | Y (mm) | Z (mm) | |||
Dual [18F]FDG and [11C]PBR28 uptake | |||||
Paraventricular hypothalamus anterior parvicellular | 0.2 | −0.5 | −4.5 | [18F]FDG = 2.06 ± 0.11 [11C]PBR28 = 1.56 ± 0.11 | [18F]FDG = 2.36 ± 0.11 [11C]PBR28 = 2.07 ± 0.14 |
CA1 Hippocampus pyramidal cell layer | −3.3 | − 3.5 | − 4.1 | [18F]FDG = 2.02 ± 0.03 [11C]PBR28 = 1.87 ± 0.15 | [18F]FDG = 2.28 ± 0.10 [11C]PBR28 = 2.23 ± 0.11 |
CA1 Hippocampus pyramidal cell layer | 3.4 | −3.3 | −4.0 | ||
LP Thalamic nucleus laterocaudal | −1.9 | − 2.8 | − 2.6 | [18F]FDG = 2.07 ± 0.08 [11C]PBR28 = 1.45 ± 0.05 | [18F]FDG = 2.34 ± 0.06 [11C]PBR28 = 1.75 ± 0.11 |
[18F]FDG uptake | |||||
Glomerular layer olfactory | 0.0 0.0 −0.2 | 4.4 5.2 5.5 | −2.9 − 3.4 − 2.8 | 2.14 ± 0.10 | 2.71 ± 0.26 |
Periaqueductal grey | −2.3 | − 2.8 | −2.9 | 2.12 ± 0.07 | 2.50 ± 0.21 |
CA1 Pyramidal layer hippocampus | 3.3 | −3.0 | −3.4 | 1.99 ± 0.03 | 2.28 ± 0.13 |
Red nucleus parvicell part | − 0.6 | −3.2 | − 3.8 | 2.29 ± 0.21 | 2.83 ± 0.14 |
Posterior thalamic nucleus | −1.0 | −3.4 | − 3.4 | 2.09 ± 0.08 | 2.37 ± 0.07 |
[11C]PBR28 uptake | |||||
Tuberal region lateral hypothalamus | 0.9 | −0.9 | −5.2 | 1.56 ± 0.11 | 2.07 ± 0.14 |
Medial amygdalar nucleus posterodorsal | 1.8 | −1.4 | −5.2 | 1.85 ± 0.10 | 2.34 ± 0.10 |
Parasubthalamic nucleus | 1.3 | −2.1 | −5.0 | 1.45 ± 0.05 | 1.75 ± 0.11 |
Caudomedial entorhinal | 3.5 3.2 | −5.1 − 5.1 | −4.1 − 4.6 | 1.87 ± 0.15 | 2.23 ± 0.11 |