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Fig. 9 | Bioelectronic Medicine

Fig. 9

From: Sympathetic innervation of human and porcine spleens: implications for between species variation in function

Fig. 9

Double-labeling IHC in porcine spleen tissue for TH (brown) and CD3 (red). A CD3 + T leukocytes are densely packed around central arterioles (ca.). TH + nerves extend from the nerve bundles (nb) into the surrounding parenchyma. B Higher magnification image of panel A showing the close association of TH + nerves and CD3 + T leukocytes both around the central arteriole and in the surrounding parenchyma, indicated by arrows. C TH + nerves and CD3 + T leukocytes are tightly packed around the central artery (ca.) and loosely packed throughout the red pulp (rp). D Higher magnification image of panel C showing the close association of TH + nerves with CD3 + T leukocytes around the central artery, indicated by arrows. Note the nerve bundle in the top right corner. E The capsule, and trabeculae of pig spleens have less innervation. However, the red pulp is rich with sympathetic innervation and leukocytes. F Higher magnification image of panel E, showing the close apposition of TH + nerves and CD3 + T cells in the red pulp beneath the capsule in pig spleens, indicated by arrows

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