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Fig. 1 | Bioelectronic Medicine

Fig. 1

From: Importance of timing optimization for closed-loop applications of vagus nerve stimulation

Fig. 1

Overview of VNS implementation considerations. This figure illustrates factors that can affect the development of next generation closed-loop VNS therapies. The solid arrows link general VNS implementation considerations. Disease-specific signals can be fed into algorithms on computers or other processing systems to trigger VNS. There are, however, two main considerations involved in determining the optimal timing of VNS (dotted lines): 1) the timing of stimulation with respect to a disease’s progression (A, linking the patient and affected systems) and 2) timing of stimulation with respect to recorded disease-specific events (B, linking the sensor(s) and stimulation control devices). Multiple paths and design choices can be considered for constructing a VNS system (Created, in part, via Biorender.com)

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