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Fig. 6 | Bioelectronic Medicine

Fig. 6

From: Vagus nerve stimulation in the non-human primate: implantation methodology, characterization of nerve anatomy, target engagement and experimental applications

Fig. 6

Assessment of neurochemical activity via PET. A Sagital, coronal and axial (left to right) PET images illustrating [11C]Raclopride, a selective antagonist on D2 dopamine receptors, uptake in the brain of one NHP. Consistent with its higer densisty of dopaminergic terminals, the striatum appears brighter than other regions demonstrating higher concentrations of the PET tracer. B Time activity curves for [11C]Raclopride within the striatum for VNS (blue) and control (orange) conditions. VNS increased binding of the tracer indicating a decrease of endogenous dopamine compared to control

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Bioelectronic Medicine

ISSN: 2332-8886