MAP depressor responses induced by DPN stimulation. Optimal stimulation parameters were evaluated in WKY and SHR animals. Representative MAP depressor responses after hook electrical stimulation (STIM) of the DPN nerve of an SHR animal. (A) There was no effect on HR (top) and robust decrease in the MAP (bottom) in response to gradual increment in stimulus intensity under three different parameters. (B) MAP also decreases proportional to the number of stimulation pulses at 0.3 mA and 1-Hz stimulation. (C) MAP depression in response to increased stimulation frequency from 1 to 100 Hz at 0.3 mA, 10 pulses.