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Figure 2 | Bioelectronic Medicine

Figure 2

From: Single-Pulse and Unidirectional Electrical Activation of the Cervical Vagus Nerve Reduces Tumor Necrosis Factor in Endotoxemia

Figure 2

The stimulation-threshold current for the inflammatory reflex is similar in rats and mice. (A) Rats were subjected to endotoxemia after vagus nerve stimulation at increasing stimulation current intensities, and concentration of TNF measured in blood. R and C indicate rostral or caudal placement of the cathodic lead, respectively (n = 8 to 27 per group). (B) Mice were subjected to cervical vagus nerve stimulation using increasing stimulation current intensities and subjected to endotoxemia. The concentration of TNF measured in blood. Means ± SEM are plotted. **p < 0.01; ***p < 0.001; NS, not significant.

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Bioelectronic Medicine

ISSN: 2332-8886