Articles

Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications

Almost 100 years ago experiments involving electrically stimulating and recording from the brain and the body launched new discoveries and debates on how electricity, movement, and thoughts are related. Decade...

Authors: Santosh Chandrasekaran, Matthew Fifer, Stephan Bickel, Luke Osborn, Jose Herrero, Breanne Christie, Junqian Xu, Rory K. J. Murphy, Sandeep Singh, Matthew F. Glasser, Jennifer L. Collinger, Robert Gaunt, Ashesh D. Mehta, Andrew Schwartz and Chad E. Bouton

A method to quantify autonomic nervous system function in healthy, able-bodied individuals

The autonomic nervous system (ANS) maintains physiological homeostasis in various organ systems via parasympathetic and sympathetic branches. ANS function is altered in common diffuse and focal conditions and ...

Authors: Shubham Debnath, Todd J. Levy, Mayer Bellehsen, Rebecca M. Schwartz, Douglas P. Barnaby, Stavros Zanos, Bruce T. Volpe and Theodoros P. Zanos

Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography

Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical comp...

Authors: Andrew Perley, Mehrdad Roustaei, Marcelo Aguilar-Rivera, David C. Kunkel, Tzung K. Hsiai, Todd P. Coleman and Parinaz Abiri

Low frequency conduction block: a promising new technique to advance bioelectronic medicines

Nerve conduction block is an appealing way to selective target the nervous system for treating pathological conditions. Several modalities were described in the past, with the kilohertz frequency stimulation g...

Authors: Silvia V. Conde

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of to...

Authors: Timir Datta-Chaudhuri

In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block

This paper describes a method to reversibly block nerve conduction through direct application of a 1 Hz sinusoidal current waveform delivered through a bipolar nerve cuff electrode. This low frequency alternat...

Authors: Maria Ivette Muzquiz, Lindsay Richardson, Christian Vetter, Macallister Smolik, Awadh Alhawwash, Adam Goodwill, Rizwan Bashirullah, Michael Carr and Ken Yoshida

Overview of therapeutic applications of non-invasive vagus nerve stimulation: a motivation for novel treatments for systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disorder that commonly affects the skin, joints, kidneys, and central nervous system. Although great progress has been made over the years, p...

Authors: Charrise M. Ramkissoon, Amparo Güemes and Josep Vehi

The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future

There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit “Technology targeting m...

Authors: Timir Datta-Chaudhuri, Theodoros Zanos, Eric H. Chang, Peder S. Olofsson, Stephan Bickel, Chad Bouton, Daniel Grande, Loren Rieth, Cynthia Aranow, Ona Bloom, Ashesh D. Mehta, Gene Civillico, Molly M. Stevens, Eric Głowacki, Christopher Bettinger, Martin Schüettler…

Progress and challenges of implantable neural interfaces based on nature-derived materials

Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-mot...

Authors: Eugenio Redolfi Riva and Silvestro Micera

How artificial intelligence can help us ‘Choose Wisely’

The overuse of low value medical tests and treatments drives costs and patient harm. Efforts to address overuse, such as Choosing Wisely campaigns, typically rely on passive implementation strategies- a form o...

Authors: Nishila Mehta, Karen Born and Benjamin Fine

Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders

Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the ...

Authors: Shichun Peng, Vijay Dhawan, David Eidelberg and Yilong Ma

Effect of defibrillation on the performance of an implantable vagus nerve stimulation system

Vagus Nerve Stimulation (VNS) delivers Autonomic Regulation Therapy (ART) for heart failure (HF), and has been associated with improvement in cardiac function and heart failure symptoms. VNS is delivered using...

Authors: Imad Libbus, Scott R. Stubbs, Scott T. Mazar, Scott Mindrebo, Bruce H. KenKnight and Lorenzo A. DiCarlo

Changing the tune using bioelectronics

The desire to harness electricity for improving human health dates back at least two millennia. As electrical signals form the basis of communication within our nervous system, the ability to monitor, control,...

Authors: Eric H. Chang

Cut wires: The Electrophysiology of Regenerated Tissue

When nerves are damaged by trauma or disease, they are still capable of firing off electrical command signals that originate from the brain. Furthermore, those damaged nerves have an innate ability to partiall...

Authors: Alexis L. Lowe and Nitish V. Thakor

Abstracts from the Fourth Bioelectronic Medicine Summit: Technology Targeting Molecular Mechanisms

Authors:

Immunity and the carotid body: implications for metabolic diseases

Neuro-immune communication has gained enormous interest in recent years due to increasing knowledge of the way in which the brain coordinates functional alterations in inflammatory and autoimmune responses, an...

Authors: Silvia V. Conde, Joana F. Sacramento and Fatima O. Martins

Recent progress on peripheral neural interface technology towards bioelectronic medicine

Modulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate exten...

Authors: Youngjun Cho, Jaeu Park, Chengkuo Lee and Sanghoon Lee

Autonomic balance determines the severity of COVID-19 courses

COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failu...

Authors: M. Leitzke, D. Stefanovic, J.-J. Meyer, S. Schimpf and P. Schönknecht

The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia

Recent evidence demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagates in intestinal epithelial cells expressing Angiotensin-Converting Enzyme 2 (ACE2), implying that these c...

Authors: Anne S. ten Hove, David J. Brinkman, Andrew Y. F. Li Yim, Caroline Verseijden, Theo B. M. Hakvoort, Iris Admiraal, Olaf Welting, Patricia H. P. van Hamersveld, Valérie Sinniger, Bruno Bonaz, Misha D. Luyer and Wouter J. de Jonge

Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs

Peripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing environmental conditions. Electrical nerve stimulation is commonly used to ac...

Authors: Victoria Cotero, Tzu-Jen Kao, John Graf, Jeffrey Ashe, Christine Morton, Sangeeta S. Chavan, Stavros Zanos, Kevin J. Tracey and Christopher M. Puleo

Single arm prospective multicenter case series on the use of burst stimulation to improve pain and motor symptoms in Parkinson’s disease

In this study we analyze new clinical data in the use of spinal cord stimulation (SCS) for the treatment of pain and motor symptoms in patients with Parkinson’s Disease (PD), as both a singular bioelectric the...

Authors: Krishnan V. Chakravarthy, Rahul Chaturvedi, Takashi Agari, Hirokazu Iwamuro, Rajiv Reddy and Ayano Matsui

Cortical stimulation in pharmacoresistant focal epilepsies

Pharmacoresistance and adverse drug events designate a considerable group of patients with focal epilepsies that require alternative treatments such as neurosurgical intervention and neurostimulation. Electric...

Authors: Jens Ellrich

Determining grasp selection from arm trajectories via deep learning to enable functional hand movement in tetraplegia

Cervical spinal cord injury severely affects grasping ability of its survivors. Fortunately, many individuals with tetraplegia retain residual arm movements that allow them to reach for objects. We propose a w...

Authors: Nikunj Bhagat, Kevin King, Richard Ramdeo, Adam Stein and Chad Bouton

Ultrasound powered piezoelectric neurostimulation devices: a commentary

Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piez...

Authors: Tao Sun, Jason Wright and Timir Datta-Chaudhuri

Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19?

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the origin of the worldwide COVID-19 pandemic, is characterized by a dramatic cytokine storm in some critical patients with COVID-19. This storm...

Authors: Bruno Bonaz, Valérie Sinniger and Sonia Pellissier

Machine learning to assist clinical decision-making during the COVID-19 pandemic

The number of cases from the coronavirus disease 2019 (COVID-19) global pandemic has overwhelmed existing medical facilities and forced clinicians, patients, and families to make pivotal decisions with limited...

Authors: Shubham Debnath, Douglas P. Barnaby, Kevin Coppa, Alexander Makhnevich, Eun Ji Kim, Saurav Chatterjee, Viktor Tóth, Todd J. Levy, Marc d. Paradis, Stuart L. Cohen, Jamie S. Hirsch and Theodoros P. Zanos

Parameters matter: modulating cytokines using nerve stimulation

The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients ...

Authors: Bruno Bonaz

Ultrasound-driven piezoelectric current activates spinal cord neurocircuits and restores locomotion in rats with spinal cord injury

Neuromodulation via electrical stimulation (ES) is a common technique to treat numerous brain and spinal cord related neurological conditions. In the present study, we examined the efficacy of piezoelectric st...

Authors: Shuai Li, Monzurul Alam, Rakib Uddin Ahmed, Hui Zhong, Xiao-Yun Wang, Serena Ng and Yong-Ping Zheng

A computational outlook on neurostimulation

Efficient identification of effective neurostimulation strategies is critical due to the growing number of clinical applications and the increasing complexity of the corresponding technology. In consequence, i...

Authors: Marco Capogrosso and Scott F. Lempka

Closed-loop bioelectronic medicine for diabetes management

Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary resea...

Authors: Amparo Güemes Gonzalez, Ralph Etienne-Cummings and Pantelis Georgiou

A review of the bioelectronic implications of stimulation of the peripheral nervous system for chronic pain conditions

Peripheral Nerve Stimulation has been used to treat human disease including pain for several decades. Innovation has made it a more viable option for treatment of common chronic pain processes, and interest in...

Authors: Timothy R. Deer, Ramana Naidu, Natalie Strand, Dawn Sparks, Alaa Abd-Elsayed, Hemant Kalia, Jennifer M. Hah, Pankaj Mehta, Dawood Sayed and Amitabh Gulati

Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation

Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacio...

Authors: Téa Tsaava, Timir Datta-Chaudhuri, Meghan E. Addorisio, Emily Battinelli Masi, Harold A. Silverman, Justin E. Newman, Gavin H. Imperato, Chad Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Eric H. Chang

Auricular neural stimulation as a new non-invasive treatment for opioid detoxification

The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are ...

Authors: Imran S. Qureshi, Timir Datta-Chaudhuri, Kevin J. Tracey, Valentin A. Pavlov and Andrew C. H. Chen

Correction to: Biomarkers and neuromodulation techniques in substance use disorders

The original version of this article [1], published on 17 February 2020, contained incorrect sentence.

Authors: Bettina Habelt, Mahnaz Arvaneh, Nadine Bernhardt and Ivan Minev

Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects

Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms incl...

Authors: Yi Cai, Rajiv D. Reddy, Vishal Varshney and Krishnan V. Chakravarthy

Biomarkers and neuromodulation techniques in substance use disorders

Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcrania...

Authors: Bettina Habelt, Mahnaz Arvaneh, Nadine Bernhardt and Ivan Minev

Neural reflex control of vascular inflammation

Atherosclerosis is a multifactorial chronic inflammatory disease that underlies myocardial infarction and stroke. Efficacious treatment for hyperlipidemia and hypertension has significantly reduced morbidity a...

Authors: A. S. Caravaca, M. Centa, A. L. Gallina, L. Tarnawski and P. S. Olofsson

Building a bioelectronic medicine movement 2019: insights from leaders in industry, academia, and research

In April 2019, a select group of medical, academic, and private-sector leaders in bioelectronic medicine convened in Geneva to discuss the potential for building a cross-disciplinary movement that would advanc...

Authors:

Correction to: Prospective trial examining safety and efficacy of microcurrent stimulation for the treatment of sinus pain and congestion

The original version of this article (Goldsobel et al. 2019), published on 20 November 2019, contained incorrect data. In this Correction the affected parts of the article are shown.

Authors: Alan B. Goldsobel, Niveditha Prabhakar and Blake T. Gurfein

Pulmonary arterial hypertension: the case for a bioelectronic treatment

Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive ...

Authors: Despοina Ntiloudi, Khaled Qanud, Jacquelyn-Nicole Tomaio, George Giannakoulas, Yousef Al-Abed and Stavros Zanos

Prospective trial examining safety and efficacy of microcurrent stimulation for the treatment of sinus pain and congestion

Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants. Sinonasal inflammation can cause symptoms of nasal c...

Authors: Alan B. Goldsobel, Niveditha Prabhakar and Blake T. Gurfein

Closed-loop neuromuscular electrical stimulation using feedforward-feedback control and textile electrodes to regulate grasp force in quadriplegia

Transcutaneous neuromuscular electrical stimulation is routinely used in physical rehabilitation and more recently in brain-computer interface applications for restoring movement in paralyzed limbs. Due to var...

Authors: John Ciancibello, Kevin King, Milad Alizadeh Meghrazi, Subash Padmanaban, Todd Levy, Richard Ramdeo, Malgorzata Straka and Chad Bouton

Neuromodulation as a new avenue for resuscitation in hemorrhagic shock

Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid th...

Authors: Keren Powell, Kevin Shah, Caleb Hao, Yi-Chen Wu, Aashish John, Raj K. Narayan and Chunyan Li

Homeostatic activity regulation as a mechanism underlying the effect of brain stimulation

Hyperexcitability of the neural network often occurs after brain injuries or degeneration and is a key pathophysiological feature in certain neurological diseases such as epilepsy, neuropathic pain, and tinnit...

Authors: Zhi Chai, Cungen Ma and Xiaoming Jin

3D-bioprinted tracheal reconstruction: an overview

Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheosto...

Authors: Lidia Frejo and Daniel A. Grande

Neural activity regulates autoimmune diseases through the gateway reflex

The brain, spinal cord and retina are protected from blood-borne compounds by the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB) and blood-retina barrier (BRB) respectively, which create a physica...

Authors: Andrea Stofkova and Masaaki Murakami

Neuroimmunomodulation of tissue injury and disease: an expanding view of the inflammatory reflex pathway

Neuroimmunomodulation through peripheral nerve activation is an important therapeutic approach to various disorders. Central to this approach is the inflammatory reflex pathway in which the cholinergic anti-in...

Authors: Shinji Tanaka, Benjamin Hammond, Diane L. Rosin and Mark D. Okusa

Non-invasive treatment of patients with upper extremity spasticity following stroke using paired trans-spinal and peripheral direct current stimulation

Muscle spasticity is a common impediment to motor recovery in patients with chronic stroke. Standard-of-care treatments such as botulinum toxin injections can temporarily relieve muscle stiffness and pain asso...

Authors: Alexandra Paget-Blanc, Johanna L. Chang, Maira Saul, Regina Lin, Zaghloul Ahmed and Bruce T. Volpe

Neurorestorative interventions involving bioelectronic implants after spinal cord injury

In the absence of approved treatments to repair damage to the central nervous system, the role of neurosurgeons after spinal cord injury (SCI) often remains confined to spinal cord decompression and vertebral ...

Authors: Newton Cho, Jordan W. Squair, Jocelyne Bloch and Grégoire Courtine

Identification of hypoglycemia-specific neural signals by decoding murine vagus nerve activity

Glucose is a crucial energy source. In humans, it is the primary sugar for high energy demanding cells in brain, muscle and peripheral neurons. Deviations of blood glucose levels from normal levels for an exte...

Authors: Emily Battinelli Masi, Todd Levy, Tea Tsaava, Chad E. Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Theodoros P. Zanos