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  3. Noninvasive ultrasound (US) has been used therapeutically for decades, with applications in tissue ablation, lithotripsy, and physical therapy. There is increasing evidence that low intensity US stimulation of...

    Authors: Claire R. W. Kaiser, Adam B. Tuma, Maryam Zebarjadi, Daniel P. Zachs, Anna J. Organ, Hubert H. Lim and Morgan N. Collins
    Citation: Bioelectronic Medicine 2023 9:25
    Content type: Research article Published on:

  4. Neuroinflammation is an important biological process induced by complex interactions between immune cells and neuronal cells in the central nervous system (CNS). Recent research on the bidirectional communicat...

    Authors: Hiroki Tanaka, Rie Hasebe, Kaoru Murakami, Toshiki Sugawara, Takeshi Yamasaki and Masaaki Murakami
    Citation: Bioelectronic Medicine 2023 9:24
    Content type: Review Published on:

  5. No effective treatment for NAION with strong evidence has been established till date. The aim of this investigator-led, prospective, non-randomized, open-label, uncontrolled multi-center exploratory clinical t...

    Authors: Gen Miura, Tadami Fujiwara, Yoshihito Ozawa, Yuki Shiko, Yohei Kawasaki, Tomohiro Nizawa, Tomoaki Tatsumi, Takuji Kurimoto, Sotaro Mori, Makoto Nakamura, Hideki Hanaoka, Takayuki Baba and Shuichi Yamamoto
    Citation: Bioelectronic Medicine 2023 9:22
    Content type: Short report Published on:

  6. Vagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This study evaluated the efficacy and safety of transcutaneous auricular VNS (t...

    Authors: Benjamin Sahn, Kristine Pascuma, Nina Kohn, Kevin J. Tracey and James F. Markowitz
    Citation: Bioelectronic Medicine 2023 9:23
    Content type: Research article Published on:

  7. The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment of several neurological and inflammatory disorders. With several BEM therapies being recently approved...

    Authors: Eric H. Chang, Arielle H. Gabalski, Tomas S. Huerta, Timir Datta-Chaudhuri, Theodoros P. Zanos, Stavros Zanos, Warren M. Grill, Kevin J. Tracey and Yousef Al-Abed
    Citation: Bioelectronic Medicine 2023 9:21
    Content type: Meeting report Published on:

  8. New sensors and modulators that interact wirelessly with medical modalities unlock uncharted avenues for in situ brain recording and stimulation. Ongoing miniaturization, material refinement, and sensitization...

    Authors: Ilhan Bok, Adam Vareberg, Yash Gokhale, Suyash Bhatt, Emily Masterson, Jack Phillips, Tianxiang Zhu, Xiaoxuan Ren and Aviad Hai
    Citation: Bioelectronic Medicine 2023 9:20
    Content type: Review Published on:

  9. Eighty percent of patients infected by SARS-CoV-2 report persistence of one symptom beyond the 4-week convalescent period. Those with orthostatic tachycardia and orthostatic symptoms mimicking postural tachyca...

    Authors: Stefano Rigo, Vasile Urechie, Andrè Diedrich, Luis E. Okamoto, Italo Biaggioni and Cyndya A. Shibao
    Citation: Bioelectronic Medicine 2023 9:19
    Content type: Short report Published on:

  10. Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep...

    Authors: Florian Missey, Malin Silverå Ejneby, Ibrahima Ngom, Mary J. Donahue, Jan Trajlinek, Emma Acerbo, Boris Botzanowski, Antonino M. Cassarà, Esra Neufeld, Eric D. Glowacki, Lee Shangold, William M. Hanes and Adam Williamson
    Citation: Bioelectronic Medicine 2023 9:18
    Content type: Research article Published on:

  11. The fourth industrial revolution has led to the development and application of health monitoring sensors that are characterized by digitalization and intelligence. These sensors have extensive applications in ...

    Authors: Chan Wang, Tianyiyi He, Hong Zhou, Zixuan Zhang and Chengkuo Lee
    Citation: Bioelectronic Medicine 2023 9:17
    Content type: Review Published on:

  12. Autonomic nerve stimulation is used as a treatment for a growing number of diseases. We have previously demonstrated that application of efferent vagus nerve stimulation (eVNS) has promising glucose lowering e...

    Authors: Joel Villalobos, Sophie C. Payne, Glenn M. Ward, Sofianos Andrikopoulos, Tomoko Hyakumura, Richard J. MacIsaac and James B. Fallon
    Citation: Bioelectronic Medicine 2023 9:16
    Content type: Research article Published on:

  13. The purpose of this study was to evaluate if kilohertz frequency alternating current (KHFAC) stimulation of peripheral nerve could serve as a treatment for lumbar radiculopathy. Prior work shows that KHFAC sti...

    Authors: Lauren Savannah Dewberry, Ken Porche, Travis Koenig, Kyle D. Allen and Kevin J. Otto
    Citation: Bioelectronic Medicine 2023 9:15
    Content type: Research article Published on:

  15. Neurostimulation is an effective therapy for treating and management of refractory chronic pain. However, the complex nature of pain and infrequent in-clinic visits, determining subject’s long-term response to...

    Authors: Robert Heros, Denis Patterson, Frank Huygen, Ioannis Skaribas, David Schultz, Derron Wilson, Michael Fishman, Steven Falowski, Gregory Moore, Jan Willem Kallewaard, Soroush Dehghan, Anahita Kyani and Misagh Mansouri
    Citation: Bioelectronic Medicine 2023 9:13
    Content type: Research article Published on:

  16. Collection of electroencephalographic (EEG) data provides an opportunity to non-invasively study human brain plasticity, learning and the evolution of various neuropsychiatric disorders. Traditionally, due to ...

    Authors: Richard James Sugden, Viet-Linh Luke Pham-Kim-Nghiem-Phu, Ingrid Campbell, Alberto Leon and Phedias Diamandis
    Citation: Bioelectronic Medicine 2023 9:12
    Content type: Review Published on:

  17. Trunk stability is crucial for people with trunk paralysis resulting from spinal cord injuries (SCI), as it plays a significant role in performing daily life activities and preventing from fall-related acciden...

    Authors: Niraj Singh Tharu, Arnold Yu Lok Wong and Yong-Ping Zheng
    Citation: Bioelectronic Medicine 2023 9:11
    Content type: Review Published on:

    The Correction to this article has been published in Bioelectronic Medicine 2023 9:14

  18. Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is becoming increasingly prevalent as our population ages. It is characterized by the buildup of amyloid beta plaques and neurofibrillary tan...

    Authors: Claire Benwood, Jonathan Walters-Shumka, Kali Scheck and Stephanie M. Willerth
    Citation: Bioelectronic Medicine 2023 9:10
    Content type: Research article Published on:

  19. Vagus nerve stimulation (VNS) is a FDA approved therapy regularly used to treat a variety of neurological disorders that impact the central nervous system (CNS) including epilepsy and stroke. Putatively, the t...

    Authors: Aaron J. Suminski, Abigail Z. Rajala, Rasmus M. Birn, Ellie M. Mueller, Margaret E. Malone, Jared P. Ness, Caitlyn Filla, Kevin Brunner, Alan B. McMillan, Samuel O. Poore, Justin C. Williams, Dhanabalan Murali, Andrea Brzeczkowski, Samuel A. Hurley, Aaron M. Dingle, Weifeng Zeng…
    Citation: Bioelectronic Medicine 2023 9:9
    Content type: Research article Published on:

  20. In recent decades, vagus nerve stimulation (VNS) therapy has become widely used for clinical applications including epilepsy, depression, and enhancing the effects of rehabilitation. However, several questions...

    Authors: Ramanamurthy V. Mylavarapu, Vivek V. Kanumuri, Juan Pablo de Rivero Vaccari, Amrit Misra, David W. McMillan and Patrick D. Ganzer
    Citation: Bioelectronic Medicine 2023 9:8
    Content type: Mini-review Published on:

  21. There is emerging evidence that the nervous system regulates immune and metabolic alterations mediating Metabolic syndrome (MetS) pathogenesis via the vagus nerve. This study evaluated the effects of transcuta...

    Authors: Tercio Lemos de Moraes, Fernando Oliveira Costa, Danielly Gomes Cabral, Daniella Marques Fernandes, Carine Teles Sangaleti, Maria Aparecida Dalboni, Josiane Motta e Motta, Liliane Appratto de Souza, Nicola Montano, Maria Claudia Irigoyen, Michael Brines, Kevin J. Tracey, Valentin A. Pavlov and Fernanda M. Consolim Colombo
    Citation: Bioelectronic Medicine 2023 9:7
    Content type: Short report Published on:

  22. The liver is an important immunological organ and liver inflammation is part of the pathophysiology of non-alcoholic steatohepatitis, a condition that may promote cirrhosis, liver cancer, liver failure, and ca...

    Authors: Osman Ahmed, April S. Caravaca, Maria Crespo, Wanmin Dai, Ting Liu, Qi Guo, Magdalena Leiva, Guadalupe Sabio, Vladimir S. Shavva, Stephen G. Malin and Peder S. Olofsson
    Citation: Bioelectronic Medicine 2023 9:6
    Content type: Research article Published on:

  24. Epidural electrical stimulation (EES) of the spinal cord has been FDA approved and used therapeutically for decades. However, there is still not a clear understanding of the local neural substrates and consequ...

    Authors: Nishant Verma, Ben Romanauski, Danny Lam, Luis Lujan, Stephan Blanz, Kip Ludwig, Scott Lempka, Andrew Shoffstall, Bruce Knudson, Yuichiro Nishiyama, Jian Hao, Hyun-Joo Park, Erika Ross, Igor Lavrov and Mingming Zhang
    Citation: Bioelectronic Medicine 2023 9:5
    Content type: Research article Published on:

  25. Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated with therapy for heart failure, but stimulation frequency and amplitude are limited by patient tolerance. An understanding of physiolo...

    Authors: William J. Huffman, Eric D. Musselman, Nicole A. Pelot and Warren M. Grill
    Citation: Bioelectronic Medicine 2023 9:3
    Content type: Research article Published on:

  27. Chest radiographs (CXRs) are the most widely available radiographic imaging modality used to detect respiratory diseases that result in lung opacities. CXR reports often use non-standardized language that resu...

    Authors: Avantika Vardhan, Alex Makhnevich, Pravan Omprakash, David Hirschorn, Matthew Barish, Stuart L. Cohen and Theodoros P. Zanos
    Citation: Bioelectronic Medicine 2023 9:1
    Content type: Research article Published on:

  28. The vagus nerve affects innate immune responses by activating spleen-projecting sympathetic neurons, which modulate leukocyte function. Recent basic and clinical research investigating vagus nerve stimulation ...

    Authors: Logan G. Kirkland, Chloe G. Garbe, Joseph Hadaya, Paul V. Benson, Brant M. Wagener, Sanjin Tankovic and Donald B. Hoover
    Citation: Bioelectronic Medicine 2022 8:20
    Content type: Research article Published on:

  30. Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments....

    Authors: Santhoshi P. Palandira, Joseph Carrion, Lauren Turecki, Aidan Falvey, Qiong Zeng, Hui Liu, Tea Tsaava, Dov Herschberg, Michael Brines, Sangeeta S. Chavan, Eric H. Chang, An Vo, Yilong Ma, Christine N. Metz, Yousef Al-Abed, Kevin J. Tracey…
    Citation: Bioelectronic Medicine 2022 8:18
    Content type: Short report Published on:

  31. Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treatment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTField...

    Authors: Akhil Jain, Isobel Jobson, Michaela Griffin, Ruman Rahman, Stuart Smith and Frankie J. Rawson
    Citation: Bioelectronic Medicine 2022 8:17
    Content type: Research article Published on:

  32. Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In precl...

    Authors: Huan Yang, Timir Datta-Chaudhuri, Sam J. George, Bilal Haider, Jason Wong, Tyler D. Hepler, Ulf Andersson, Michael Brines, Kevin J. Tracey and Sangeeta S. Chavan
    Citation: Bioelectronic Medicine 2022 8:16
    Content type: Research article Published on:

  33. The concept of Instrumented Smart Implant emerged as a leading research topic that aims to revolutionize the field of orthopaedic implantology. These implants have been designed incorporating biophysical thera...

    Authors: Marco P. Soares dos Santos and Rodrigo M. C. Bernardo
    Citation: Bioelectronic Medicine 2022 8:15
    Content type: Mini-review Published on:

  34. Osteoarthritis (OA) is a common and debilitating condition characterized by degeneration of hyaline cartilage. Currently, there is no treatment for OA that directly targets degradation of cartilage matrix. Cap...

    Authors: Kaleb Noruzi, Pooja Swami, Lidia Frejo, Jason Wright, Jason Wong, Daniel Grande and Timir Datta-Chaudhuri
    Citation: Bioelectronic Medicine 2022 8:14
    Content type: Research article Published on:

  35. Although the coronavirus disease 19 (COVID-19) pandemic has now impacted the world for over two years, the persistent secondary neuropsychiatric effects are still not fully understood. These “long COVID” sympt...

    Authors: Bashar W. Badran, Sarah M. Huffman, Morgan Dancy, Christopher W. Austelle, Marom Bikson, Steven A. Kautz and Mark S. George
    Citation: Bioelectronic Medicine 2022 8:13
    Content type: Research article Published on:

  36. As pharmacological treatments are the primary option for opioid use disorder, neuromodulation has recently demonstrated efficacy in managing opioid withdrawal syndrome (OWS). This study investigated the safety...

    Authors: Carlos F. Tirado, Stephanie N. Washburn, Alejandro Covalin, Caroline Hedenberg, Heather Vanderpool, Caroline Benner, Daniel P. Powell, Melanie A. McWade and Navid Khodaparast
    Citation: Bioelectronic Medicine 2022 8:12
    Content type: Research article Published on:

  37. KiloHertz frequency alternating current waveforms produce conduction block in peripheral nerves. It is not clearly known how the waveform shape affects block outcomes, and if waveform effects are frequency dep...

    Authors: David B. Green, Joseph A. Kilgore, Shane A. Bender, Robert J. Daniels, Douglas D. Gunzler, Tina L. Vrabec and Niloy Bhadra
    Citation: Bioelectronic Medicine 2022 8:11
    Content type: Research article Published on:

  38. Vagus nerve stimulation (VNS) has shown therapeutic potential in a variety of different diseases with many ongoing clinical trials. The role of VNS in reducing ischemic injury in the brain requires further eva...

    Authors: Rishabh C. Choudhary, Umair Ahmed, Muhammad Shoaib, Eric Alper, Abdul Rehman, Junhwan Kim, Koichiro Shinozaki, Bruce T. Volpe, Sangeeta Chavan, Stavros Zanos, Kevin J. Tracey and Lance B. Becker
    Citation: Bioelectronic Medicine 2022 8:10
    Content type: Research article Published on:

  39. The vagus nerve is involved in the autonomic regulation of physiological homeostasis, through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of the vagus with bioelectronic d...

    Authors: Umair Ahmed, Yao-Chuan Chang, Stefanos Zafeiropoulos, Zeinab Nassrallah, Larry Miller and Stavros Zanos
    Citation: Bioelectronic Medicine 2022 8:9
    Content type: Review Published on:

  40. Spinal cord stimulation (SCS), an FDA-approved therapy for chronic pain, uses paresthesia (low frequency SCS (LF-SCS)) or paresthesia-free (such as high-frequency SCS (HF-SCS)) systems, providing analgesia thr...

    Authors: Rosalynn R. Z. Conic, Jacob Caylor, Christina L. Cui, Zabrina Reyes, Eric Nelson, Sopyda Yin and Imanuel Lerman
    Citation: Bioelectronic Medicine 2022 8:8
    Content type: Research article Published on:

  41. Dorsal Root Ganglia (DRG) neurons are derived from the neural crest and mainly innervate the skin, while Jugular Nodose Complex (JNC) neurons originate from the placode and innervate internal organs. These gan...

    Authors: Theo Crosson and Sebastien Talbot
    Citation: Bioelectronic Medicine 2022 8:7
    Content type: Short report Published on:

  42. The retrospective study provides real-world evidence for long-term clinical efficacy of electrical optic nerve stimulation (ONS) in glaucoma with progressive vision loss.

    Authors: Carl Erb, Sophie Eckert, Pia Gindorf, Martin Köhler, Thomas Köhler, Lukas Neuhann, Thomas Neuhann, Nadja Salzmann, Stefanie Schmickler and Jens Ellrich
    Citation: Bioelectronic Medicine 2022 8:6
    Content type: Research article Published on:

  43. Overactive bladder (OAB) affects 12 to 30% of the world’s population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social i...

    Authors: Hui Zhong, Emilie Liu, Priya Kohli, Laura Perez, V. Reggie Edgerton, David Ginsberg, Parag Gad and Evgeniy Kreydin
    Citation: Bioelectronic Medicine 2022 8:5
    Content type: Short report Published on:

  44. Acquired brain injuries, such as stroke, are a major cause of long-term disability worldwide. Intracortical microstimulation (ICMS) can be used successfully to assist in guiding appropriate connections to rest...

    Authors: Marta Carè, Alberto Averna, Federico Barban, Marianna Semprini, Lorenzo De Michieli, Randolph J. Nudo, David J. Guggenmos and Michela Chiappalone
    Citation: Bioelectronic Medicine 2022 8:4
    Content type: Research article Published on:

  46. Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation methods will significantly enhance the application rang...

    Authors: Marta Saccher, Shinnosuke Kawasaki, Martina Proietti Onori, Geeske M. van Woerden, Vasiliki Giagka and Ronald Dekker
    Citation: Bioelectronic Medicine 2022 8:2
    Content type: Methodology Published on:

  47. Children with frequently relapsing nephrotic syndrome (FRNS) and steroid resistant nephrotic syndrome (SRNS) are exposed to immunosuppressant medications with adverse side effects and variable efficacy. Transc...

    Authors: Kumail Merchant, Stavros Zanos, Timir Datta-Chaudhuri, Clifford S. Deutschman and Christine B. Sethna
    Citation: Bioelectronic Medicine 2022 8:1
    Content type: Short report Published on:

  48. A detailed sensorimotor evaluation is essential in planning effective, individualized therapy post-stroke. Robotic kinematic assay may offer better accuracy and resolution to understand stroke recovery. Here w...

    Authors: Caio B. Moretti, Taya Hamilton, Dylan J. Edwards, Avrielle Rykman Peltz, Johanna L. Chang, Mar Cortes, Alexandre C. B. Delbe, Bruce T. Volpe and Hermano I. Krebs
    Citation: Bioelectronic Medicine 2021 7:21
    Content type: Research article Published on:

  49. Effectiveness of robotic therapy and transcranial direct current stimulation is conventionally assessed with clinical measures. Robotic metrics may be more objective and sensitive for measuring the efficacy of...

    Authors: Caio B. Moretti, Dylan J. Edwards, Taya Hamilton, Mar Cortes, Avrielle Rykman Peltz, Johanna L. Chang, Alexandre C. B. Delbem, Bruce T. Volpe and Hermano I. Krebs
    Citation: Bioelectronic Medicine 2021 7:20
    Content type: Research article Published on:

  50. In the past three decades, we have witnessed unprecedented progress in wireless implantable medical devices that can monitor physiological parameters and interface with the nervous system. These devices are be...

    Authors: Adam Khalifa, Sunwoo Lee, Alyosha Christopher Molnar and Sydney Cash
    Citation: Bioelectronic Medicine 2021 7:19
    Content type: Mini-review Published on:
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Bioelectronic Medicine

ISSN: 2332-8886