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Reviewers of the quarter

Bioelectronic Medicine would like to recognize the efforts of its exceptional peer reviewers, for their excellent service. The following individuals have exceeded expectations as far as acceptance rate, the number of completed reviews, and timeliness, for each of the listed three-month periods. The journal cannot succeed without its peer reviewers, and we thank the hard-working members of our network.

Second Quarter of 2020

Dr. Hojjat Salmasian
Brigham and Women’s Hospital
Harvard Medical School

New Content ItemDr. Hojjat Salmasian is the Medical Director of Data Science and Analytics at Brigham and Women’s Hospital (BWH) and is also an Instructor of Medicine at Harvard Medical School (HMS). Trained in medicine and informatics, he is a leader in the use of advanced data science and informatics approaches to measure and improve quality, safety, experience, and value of healthcare. In his academic role, he leads research projects focused on improving medication safety, reducing wrong-patient order entry, measuring healthcare quality and safety, and improving the efficiency and value of healthcare delivery processes. He lectures on clinical informatics and data science, and mentors clinical informatics fellows at HMS on projects focused on digital medicine, applied clinical informatics, or the use of artificial intelligence in medicine and healthcare.

First Quarter of 2020

Eric H. Chang, Ph.D.
Feinstein Institutes for Medical Research

New Content ItemDr. Chang is a neuroscientist who works at the intersection of electrophysiology, neurology, and immunology. His research focuses on how electrical and chemical signals enable communication between the nervous system and immune system. Through the use of technologies adapted from the fields of neuroscience and bioengineering, Dr. Chang’s work is aimed at understanding how neurons and nerves in the peripheral nervous system regulate basic physiological functions and inflammatory responses in the body. Recent work in the lab has been focused on optogenetic stimulation of specific vagus nerve fibers to modulate levels of circulating proinflammatory cytokines that are chronically elevated in a host of disorders. Another recent project involves monitoring the responses of neurons to specific inflammatory mediators to determine whether neurons encode cytokine-specific information, and if so, at which level of the nervous system. These studies will provide much needed insight into how electrical signals, which are the currency of the nervous system, lead to molecular changes at the level of immune cells. 

The overarching goal of Dr. Chang’s research is to obtain a better understanding of the neural circuitry underlying neuro-immune communication. This circuit-level understanding can then be used to implement improved bioelectronic therapies for treating disease and, ultimately, improving lives. 

Fourth Quarter of 2019

Professor Sergio Iván Valdés Ferrer
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Professor Sergio Iván Valdés FerrerI'm a Neurologist-turned-scientist. My lab is broadly interested in the interactions between nervous and immune systems in health and disease. We are actively exploring the role of cholinergic agonists in HIV-induced immune dysfunction. At this moment, we are also exploring novel pharmacological approaches in patients with SARS-CoV-2 infection as a way to mitigate the inflammatory cascade leading to organ failure and death. From a clinical perspective, we are also interested in neuropsychiatric systemic lupus erythematosus, in particular in spinal cord inflammation and stroke. The lab is currently funded by the National Council of Science and Technology of Mexico (CONACyT), as well as the Pfizer Scientific Institute. We are proud to collaborate with the labs of Yi Zuo (UCSC), Kevin J. Tracey (Feinstein Institute), Roman Sankowski (Freiburg University), and José C. Crispín (INNSZ; Mexico).

Third quarter of 2019

Professor Jared Huston
Institute of Bioelectronic Medicine 
Feinstein Institutes for Medical Research


New Content ItemThe focus of Dr. Huston’s research is to understand how the central nervous system maintains homeostasis and protects against traumatic injury. Trauma is a leading cause of death and disability around the world. In the United States, the most common preventable cause of death following trauma is uncontrolled hemorrhage. Therapies to improve hemostasis are limited.

The brain monitors and regulates systemic inflammation through the vagus nerve. This pathway, termed the inflammatory reflex, is comprised of afferent and efferent vagus nerve signaling. The efferent arm, or cholinergic anti-inflammatory pathway, signals through the vagus nerve to target T lymphocytes in spleen. Acetylcholine release following vagus nerve stimulation inhibits pro-inflammatory cytokine production via the a7 nicotinic acetylcholine receptor on macrophages. Electrical or mechanical vagus nerve stimulation prevents lethal organ injury in models of systemic inflammation, shock, and sepsis.

In addition to inhibiting inflammation, vagus nerve stimulation reduces traumatic hemorrhage. Electrical vagus nerve stimulation significantly decreases blood loss and time to cessation of bleeding following peripheral soft tissue injury in swine. Vagus nerve stimulation also accelerates clot formation specifically at the site of tissue injury. These findings have also been observed in small animal models of both peripheral and visceral traumatic hemorrhage. Dr. Huston’s research group is currently investigating the mechanisms underlying these findings. This technology, known as the Neural Tourniquet, is currently undergoing clinical trials, and hopefully it will lead to improved patient outcomes following hemorrhage.

Second quarter of 2019

Professor Ulf Andersson
Karolinska Institutet

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Professor Andersson is a senior professor in pediatrics at the Karolinska Institute in Stockholm, Sweden. As a pediatrician of 45 years, he has taken care of children with inflammatory diseases. During this period, he continuously performed parallel basic studies in immunology in order to develop novel therapy and biomarkers for inflammatory diseases. The backbone of this work has been and still is formed on a close collaboration with Kevin Tracey´s research group at the Feinstein Institutes for Medical Research in New York.  Together, they have been involved in pioneering studies of the cholinergic anti-inflammatory pathway and in the discovery and exploration of HMGB1 as the archetypical alarmin.

First quarter of 2019

Professor Bruno Bonaz
Grenoble Institute of Neurosciences

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I am Professor of Gastroenterology in the Grenoble Faculty of Medicine and Hospital in Grenoble, France. I am a member of the team “Cerebral Stimulation & Systems Neuroscience” (team leader: Olivier David) at the Grenoble Institute of Neurosciences (GIN, INSERM U1216; https://neurosciences.univ-grenoble-alpes.fr/), and I was previously the team leader of the group Stress and Neurodigestive Interactions at the GIN. I have worked on brain-gut interactions for more than thirty years, both at the pre-clinical and clinical level, focusing on irritable bowel syndrome and inflammatory bowel diseases with a special interest on the role of stress and the autonomic nervous system in the physiopathology of such diseases. In particular, I am working on the anti-inflammatory (anti-TNF) properties of the vagus nerve (VN) through VN stimulation (VNS). We have shown that VNS has an anti-inflammatory role in a model of colitis in rats and, in a translational approach, we have recently published the first pilot study of VNS in patients with active Crohn’s disease. I really think that Bioelectronic Medicine, targeting the autonomic nervous system (e.g. the VN), opens new therapeutic avenues in the domain of gut inflammatory disorders and others. I am also interested in interoceptive awareness, based on the involvement of the VN in interoception, functional digestive disorders, and inflammatory bowel diseases. I am also interested in the role of complementary medicines, such as hypnosis I practice with my patients, which are known to increase and re-balance vagal tone through a homeostatic way, and I am the principal investigator of a clinical trial of hypnosis in Crohn’s disease. I am presently the President of the International Society of Autonomic Neuroscience (ISAN).


Dr Yao-Chuan Chang
Feinstein Institutes for Medical Research

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My research interests include Neural Engineering, Neurostimulation, Neuromodulation, and Optical Imaging. My current research focuses on:

  • Designing and conducting experiments on the delivery of neurostimulation strategies to peripheral nerves in a fiber-and function-specific manner.
  • Developing in vivo and in vitro assays for reading out the fiber-specific effects of peripheral neurostimulation, including methodologies from electrical and optical neurophysiology, as well as from automatic and cardiovascular physiology.
  • Designing and implementing closed-loop neuromodulation systems for the in vivo delivery of adaptive, responsive neurostimulation that observes the state of the organism and/or the organ whose function required modulation.

Annual Journal Metrics

  • Speed
    30 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    56 days from submission to acceptance
    28 days from acceptance to publication
     

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