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Reviewers of the quarter

Bioelectronic Medicine would like to recognize the efforts of its exceptional peer reviewers, for their excellent service. The following individuals have exceeded expectations as far as acceptance rate, the number of completed reviews, and timeliness, for each of the listed three-month periods. The journal cannot succeed without its peer reviewers, and we thank the hard-working members of our network.

Third quarter of 2019

Professor Jared Huston
Institute of Bioelectronic Medicine 
Feinstein Institutes for Medical Research


New Content ItemThe focus of Dr. Huston’s research is to understand how the central nervous system maintains homeostasis and protects against traumatic injury. Trauma is a leading cause of death and disability around the world. In the United States, the most common preventable cause of death following trauma is uncontrolled hemorrhage. Therapies to improve hemostasis are limited.

The brain monitors and regulates systemic inflammation through the vagus nerve. This pathway, termed the inflammatory reflex, is comprised of afferent and efferent vagus nerve signaling. The efferent arm, or cholinergic anti-inflammatory pathway, signals through the vagus nerve to target T lymphocytes in spleen. Acetylcholine release following vagus nerve stimulation inhibits pro-inflammatory cytokine production via the a7 nicotinic acetylcholine receptor on macrophages. Electrical or mechanical vagus nerve stimulation prevents lethal organ injury in models of systemic inflammation, shock, and sepsis.

In addition to inhibiting inflammation, vagus nerve stimulation reduces traumatic hemorrhage. Electrical vagus nerve stimulation significantly decreases blood loss and time to cessation of bleeding following peripheral soft tissue injury in swine. Vagus nerve stimulation also accelerates clot formation specifically at the site of tissue injury. These findings have also been observed in small animal models of both peripheral and visceral traumatic hemorrhage. Dr. Huston’s research group is currently investigating the mechanisms underlying these findings. This technology, known as the Neural Tourniquet, is currently undergoing clinical trials, and hopefully it will lead to improved patient outcomes following hemorrhage.

Second quarter of 2019

Professor Ulf Andersson
Karolinska Institutet

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Professor Andersson is a senior professor in pediatrics at the Karolinska Institute in Stockholm, Sweden. As a pediatrician of 45 years, he has taken care of children with inflammatory diseases. During this period, he continuously performed parallel basic studies in immunology in order to develop novel therapy and biomarkers for inflammatory diseases. The backbone of this work has been and still is formed on a close collaboration with Kevin Tracey´s research group at the Feinstein Institutes for Medical Research in New York.  Together, they have been involved in pioneering studies of the cholinergic anti-inflammatory pathway and in the discovery and exploration of HMGB1 as the archetypical alarmin.

First quarter of 2019

Professor Bruno Bonaz
Grenoble Institute of Neurosciences

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I am Professor of Gastroenterology in the Grenoble Faculty of Medicine and Hospital in Grenoble, France. I am a member of the team “Cerebral Stimulation & Systems Neuroscience” (team leader: Olivier David) at the Grenoble Institute of Neurosciences (GIN, INSERM U1216; https://neurosciences.univ-grenoble-alpes.fr/), and I was previously the team leader of the group Stress and Neurodigestive Interactions at the GIN. I have worked on brain-gut interactions for more than thirty years, both at the pre-clinical and clinical level, focusing on irritable bowel syndrome and inflammatory bowel diseases with a special interest on the role of stress and the autonomic nervous system in the physiopathology of such diseases. In particular, I am working on the anti-inflammatory (anti-TNF) properties of the vagus nerve (VN) through VN stimulation (VNS). We have shown that VNS has an anti-inflammatory role in a model of colitis in rats and, in a translational approach, we have recently published the first pilot study of VNS in patients with active Crohn’s disease. I really think that Bioelectronic Medicine, targeting the autonomic nervous system (e.g. the VN), opens new therapeutic avenues in the domain of gut inflammatory disorders and others. I am also interested in interoceptive awareness, based on the involvement of the VN in interoception, functional digestive disorders, and inflammatory bowel diseases. I am also interested in the role of complementary medicines, such as hypnosis I practice with my patients, which are known to increase and re-balance vagal tone through a homeostatic way, and I am the principal investigator of a clinical trial of hypnosis in Crohn’s disease. I am presently the President of the International Society of Autonomic Neuroscience (ISAN).


Dr Yao-Chuan Chang
Feinstein Institutes for Medical Research

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My research interests include Neural Engineering, Neurostimulation, Neuromodulation, and Optical Imaging. My current research focuses on:

  • Designing and conducting experiments on the delivery of neurostimulation strategies to peripheral nerves in a fiber-and function-specific manner.
  • Developing in vivo and in vitro assays for reading out the fiber-specific effects of peripheral neurostimulation, including methodologies from electrical and optical neurophysiology, as well as from automatic and cardiovascular physiology.
  • Designing and implementing closed-loop neuromodulation systems for the in vivo delivery of adaptive, responsive neurostimulation that observes the state of the organism and/or the organ whose function required modulation.

Annual Journal Metrics

  • Speed
    30 days to first decision for reviewed manuscripts only
    28 days to first decision for all manuscripts
    56 days from submission to acceptance
    28 days from acceptance to publication
     

    Usage 
    74,200 downloads
    171 mentions

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