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  1. Peripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing environmental conditions. Electrical nerve stimulation is commonly used to ac...

    Authors: Victoria Cotero, Tzu-Jen Kao, John Graf, Jeffrey Ashe, Christine Morton, Sangeeta S. Chavan, Stavros Zanos, Kevin J. Tracey and Christopher M. Puleo

    Citation: Bioelectronic Medicine 2020 6:21

    Content type: Research article

    Published on:

  2. In this study we analyze new clinical data in the use of spinal cord stimulation (SCS) for the treatment of pain and motor symptoms in patients with Parkinson’s Disease (PD), as both a singular bioelectric the...

    Authors: Krishnan V. Chakravarthy, Rahul Chaturvedi, Takashi Agari, Hirokazu Iwamuro, Rajiv Reddy and Ayano Matsui

    Citation: Bioelectronic Medicine 2020 6:18

    Content type: Short report

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  3. Pharmacoresistance and adverse drug events designate a considerable group of patients with focal epilepsies that require alternative treatments such as neurosurgical intervention and neurostimulation. Electric...

    Authors: Jens Ellrich

    Citation: Bioelectronic Medicine 2020 6:19

    Content type: Mini-review

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  4. Cervical spinal cord injury severely affects grasping ability of its survivors. Fortunately, many individuals with tetraplegia retain residual arm movements that allow them to reach for objects. We propose a w...

    Authors: Nikunj Bhagat, Kevin King, Richard Ramdeo, Adam Stein and Chad Bouton

    Citation: Bioelectronic Medicine 2020 6:17

    Content type: Short report

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  5. Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piez...

    Authors: Tao Sun, Jason Wright and Timir Datta-Chaudhuri

    Citation: Bioelectronic Medicine 2020 6:16

    Content type: Commentary

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    The original article was published in Bioelectronic Medicine 2020 6:13

  6. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the origin of the worldwide COVID-19 pandemic, is characterized by a dramatic cytokine storm in some critical patients with COVID-19. This storm...

    Authors: Bruno Bonaz, Valérie Sinniger and Sonia Pellissier

    Citation: Bioelectronic Medicine 2020 6:15

    Content type: Hypothesis

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  7. The number of cases from the coronavirus disease 2019 (COVID-19) global pandemic has overwhelmed existing medical facilities and forced clinicians, patients, and families to make pivotal decisions with limited...

    Authors: Shubham Debnath, Douglas P. Barnaby, Kevin Coppa, Alexander Makhnevich, Eun Ji Kim, Saurav Chatterjee, Viktor Tóth, Todd J. Levy, Marc d. Paradis, Stuart L. Cohen, Jamie S. Hirsch and Theodoros P. Zanos

    Citation: Bioelectronic Medicine 2020 6:14

    Content type: Perspective

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  8. The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients ...

    Authors: Bruno Bonaz

    Citation: Bioelectronic Medicine 2020 6:12

    Content type: Commentary

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    The Research article to this article has been published in Bioelectronic Medicine 2020 6:8

  9. Neuromodulation via electrical stimulation (ES) is a common technique to treat numerous brain and spinal cord related neurological conditions. In the present study, we examined the efficacy of piezoelectric st...

    Authors: Shuai Li, Monzurul Alam, Rakib Uddin Ahmed, Hui Zhong, Xiao-Yun Wang, Serena Ng and Yong-Ping Zheng

    Citation: Bioelectronic Medicine 2020 6:13

    Content type: Short report

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    The Commentary to this article has been published in Bioelectronic Medicine 2020 6:16

  10. Efficient identification of effective neurostimulation strategies is critical due to the growing number of clinical applications and the increasing complexity of the corresponding technology. In consequence, i...

    Authors: Marco Capogrosso and Scott F. Lempka

    Citation: Bioelectronic Medicine 2020 6:10

    Content type: Perspective

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  11. Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary resea...

    Authors: Amparo Güemes Gonzalez, Ralph Etienne-Cummings and Pantelis Georgiou

    Citation: Bioelectronic Medicine 2020 6:11

    Content type: Mini-review

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  12. Peripheral Nerve Stimulation has been used to treat human disease including pain for several decades. Innovation has made it a more viable option for treatment of common chronic pain processes, and interest in...

    Authors: Timothy R. Deer, Ramana Naidu, Natalie Strand, Dawn Sparks, Alaa Abd-Elsayed, Hemant Kalia, Jennifer M. Hah, Pankaj Mehta, Dawood Sayed and Amitabh Gulati

    Citation: Bioelectronic Medicine 2020 6:9

    Content type: Review

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  13. Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacio...

    Authors: Téa Tsaava, Timir Datta-Chaudhuri, Meghan E. Addorisio, Emily Battinelli Masi, Harold A. Silverman, Justin E. Newman, Gavin H. Imperato, Chad Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Eric H. Chang

    Citation: Bioelectronic Medicine 2020 6:8

    Content type: Research article

    Published on:

    The original article was published in Bioelectronic Medicine 2020 6:12

  14. The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are ...

    Authors: Imran S. Qureshi, Timir Datta-Chaudhuri, Kevin J. Tracey, Valentin A. Pavlov and Andrew C. H. Chen

    Citation: Bioelectronic Medicine 2020 6:7

    Content type: Mini-review

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  15. Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms incl...

    Authors: Yi Cai, Rajiv D. Reddy, Vishal Varshney and Krishnan V. Chakravarthy

    Citation: Bioelectronic Medicine 2020 6:5

    Content type: Mini-review

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  16. Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcrania...

    Authors: Bettina Habelt, Mahnaz Arvaneh, Nadine Bernhardt and Ivan Minev

    Citation: Bioelectronic Medicine 2020 6:4

    Content type: Review

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    The Correction to this article has been published in Bioelectronic Medicine 2020 6:6

  17. Atherosclerosis is a multifactorial chronic inflammatory disease that underlies myocardial infarction and stroke. Efficacious treatment for hyperlipidemia and hypertension has significantly reduced morbidity a...

    Authors: A. S. Caravaca, M. Centa, A. L. Gallina, L. Tarnawski and P. S. Olofsson

    Citation: Bioelectronic Medicine 2020 6:3

    Content type: Review

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  18. The original version of this article (Goldsobel et al. 2019), published on 20 November 2019, contained incorrect data. In this Correction the affected parts of the article are shown.

    Authors: Alan B. Goldsobel, Niveditha Prabhakar and Blake T. Gurfein

    Citation: Bioelectronic Medicine 2020 6:2

    Content type: Correction

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    The original article was published in Bioelectronic Medicine 2019 5:18

  19. Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive ...

    Authors: Despοina Ntiloudi, Khaled Qanud, Jacquelyn-Nicole Tomaio, George Giannakoulas, Yousef Al-Abed and Stavros Zanos

    Citation: Bioelectronic Medicine 2019 5:20

    Content type: Review

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  20. Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants. Sinonasal inflammation can cause symptoms of nasal c...

    Authors: Alan B. Goldsobel, Niveditha Prabhakar and Blake T. Gurfein

    Citation: Bioelectronic Medicine 2019 5:18

    Content type: Research article

    Published on:

    The Correction to this article has been published in Bioelectronic Medicine 2020 6:2

  21. Transcutaneous neuromuscular electrical stimulation is routinely used in physical rehabilitation and more recently in brain-computer interface applications for restoring movement in paralyzed limbs. Due to var...

    Authors: John Ciancibello, Kevin King, Milad Alizadeh Meghrazi, Subash Padmanaban, Todd Levy, Richard Ramdeo, Malgorzata Straka and Chad Bouton

    Citation: Bioelectronic Medicine 2019 5:19

    Content type: Short report

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  22. Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid th...

    Authors: Keren Powell, Kevin Shah, Caleb Hao, Yi-Chen Wu, Aashish John, Raj K. Narayan and Chunyan Li

    Citation: Bioelectronic Medicine 2019 5:17

    Content type: Mini-review

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  23. Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheosto...

    Authors: Lidia Frejo and Daniel A. Grande

    Citation: Bioelectronic Medicine 2019 5:15

    Content type: Mini-review

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  24. Neuroimmunomodulation through peripheral nerve activation is an important therapeutic approach to various disorders. Central to this approach is the inflammatory reflex pathway in which the cholinergic anti-in...

    Authors: Shinji Tanaka, Benjamin Hammond, Diane L. Rosin and Mark D. Okusa

    Citation: Bioelectronic Medicine 2019 5:13

    Content type: Review

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  25. Muscle spasticity is a common impediment to motor recovery in patients with chronic stroke. Standard-of-care treatments such as botulinum toxin injections can temporarily relieve muscle stiffness and pain asso...

    Authors: Alexandra Paget-Blanc, Johanna L. Chang, Maira Saul, Regina Lin, Zaghloul Ahmed and Bruce T. Volpe

    Citation: Bioelectronic Medicine 2019 5:11

    Content type: Research article

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  26. Glucose is a crucial energy source. In humans, it is the primary sugar for high energy demanding cells in brain, muscle and peripheral neurons. Deviations of blood glucose levels from normal levels for an exte...

    Authors: Emily Battinelli Masi, Todd Levy, Tea Tsaava, Chad E. Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Theodoros P. Zanos

    Citation: Bioelectronic Medicine 2019 5:9

    Content type: Research article

    Published on:

  27. Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers an implantable, non-pharmacologic treatment for patients with intractable chronic pain conditions. Chronic pain is ...

    Authors: Jacob Caylor, Rajiv Reddy, Sopyda Yin, Christina Cui, Mingxiong Huang, Charles Huang, Ramesh Rao, Dewleen G. Baker, Alan Simmons, Dmitri Souza, Samer Narouze, Ricardo Vallejo and Imanuel Lerman

    Citation: Bioelectronic Medicine 2019 5:12

    Content type: Review

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  28. This article [1] has been retracted at the request of the author due to significant overlap with one of his other publications [2] without proper citation. This article is considered redundant. The author agre...

    Authors: Damian Miles Bailey

    Citation: Bioelectronic Medicine 2019 5:7

    Content type: Retraction Note

    Published on:

    The original article was published in Bioelectronic Medicine 2018 4:13

  29. Glutamatergic neurons represent the largest neuronal class in the brain and are responsible for the bulk of excitatory synaptic transmission and plasticity. Abnormalities in glutamatergic neurons are linked to...

    Authors: Eric H. Chang, Samantha T. Carreiro, Stephen A. Frattini and Patricio T. Huerta

    Citation: Bioelectronic Medicine 2019 5:6

    Content type: Research article

    Published on:

  30. Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory disease characterized by extensive joint tissue inflammation. Implantable bioelectronic devices targeting the inflammatory reflex reduce TNF...

    Authors: Meghan E. Addorisio, Gavin H. Imperato, Alex F. de Vos, Steve Forti, Richard S. Goldstein, Valentin A. Pavlov, Tom van der Poll, Huan Yang, Betty Diamond, Kevin J. Tracey and Sangeeta S. Chavan

    Citation: Bioelectronic Medicine 2019 5:4

    Content type: Research article

    Published on:

  31. The loss of motor functions resulting from spinal cord injury can have devastating implications on the quality of one’s life. Functional electrical stimulation has been used to help restore mobility, however, ...

    Authors: Autumn J. Bullard, Samuel R. Nason, Zachary T. Irwin, Chrono S. Nu, Brian Smith, Alex Campean, P. Hunter Peckham, Kevin L. Kilgore, Matthew S. Willsey, Parag G. Patil and Cynthia A. Chestek

    Citation: Bioelectronic Medicine 2019 5:3

    Content type: Research article

    Published on:

  32. The Cleveland Neural Engineering Workshop (NEW) was established as a biennial meeting in 2011, with subsequent meetings taking place in 2013, 2015, and most recently, June 2017. This fourth biennial NEW was ho...

    Authors: Dustin J. Tyler, Christopher J. Czura, Jennifer French, Kip Ludwig, Kevin Otto, Forrest Pape and Cristin Welle

    Citation: Bioelectronic Medicine 2019 5:2

    Content type: Meeting report

    Published on:

  33. The Cleveland Neural Engineering Workshop (NEW) is a biennial meeting started in 2011 as an “unconference” to bring together leaders in the neural engineering and related fields. Since the first iteration of t...

    Authors: Kim Anderson, Abidemi Ajiboye, Timothy Denison, Jennifer French, Kenneth Gustafson, Kevin Kilgore, Naomi Kleitman, Audrey Kusiak, Brian Litt, Megan Moynahan, Eric Perreault, Douglas Weber, Justin Williams and Dustin Tyler

    Citation: Bioelectronic Medicine 2018 4:15

    Content type: Meeting report

    Published on:

  34. Rising atmospheric oxygen (O2) levels provided a selective pressure for the evolution of O2-dependent micro-organisms that began with the autotrophic eukaryotes. Since these primordial times, the respiring mammal...

    Authors: Damian Miles Bailey

    Citation: Bioelectronic Medicine 2018 4:13

    Content type: Review

    Published on:

    The Retraction Note to this article has been published in Bioelectronic Medicine 2019 5:7

  35. Understanding the long-term behavior of intracortically-recorded signals is essential for improving the performance of Brain Computer Interfaces. However, few studies have systematically investigated chronic n...

    Authors: Mingming Zhang, Michael A. Schwemmer, Jordyn E. Ting, Connor E. Majstorovic, David A. Friedenberg, Marcia A. Bockbrader, W. Jerry Mysiw, Ali R. Rezai, Nicholas V. Annetta, Chad E. Bouton, Herbert S. Bresler and Gaurav Sharma

    Citation: Bioelectronic Medicine 2018 4:11

    Content type: Research article

    Published on:

  36. The role of the kidney in glucose homeostasis has gained global interest. Kidneys are innervated by renal nerves, and renal denervation animal models have shown improved glucose regulation. We hypothesized tha...

    Authors: Ahmad A. Jiman, Kavaljit H. Chhabra, Alfor G. Lewis, Paul S. Cederna, Randy J. Seeley, Malcolm J. Low and Tim M. Bruns

    Citation: Bioelectronic Medicine 2018 4:7

    Content type: Research article

    Published on:

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