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Articles
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Citation: Bioelectronic Medicine 2023 9(Suppl 1):4
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Characterization and applications of evoked responses during epidural electrical stimulation
Epidural electrical stimulation (EES) of the spinal cord has been FDA approved and used therapeutically for decades. However, there is still not a clear understanding of the local neural substrates and consequ...
Citation: Bioelectronic Medicine 2023 9:5 -
Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles
Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated with therapy for heart failure, but stimulation frequency and amplitude are limited by patient tolerance. An understanding of physiolo...
Citation: Bioelectronic Medicine 2023 9:3 -
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?
Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other un...
Citation: Bioelectronic Medicine 2023 9:2 -
A radiographic, deep transfer learning framework, adapted to estimate lung opacities from chest x-rays
Chest radiographs (CXRs) are the most widely available radiographic imaging modality used to detect respiratory diseases that result in lung opacities. CXR reports often use non-standardized language that resu...
Citation: Bioelectronic Medicine 2023 9:1 -
Sympathetic innervation of human and porcine spleens: implications for between species variation in function
The vagus nerve affects innate immune responses by activating spleen-projecting sympathetic neurons, which modulate leukocyte function. Recent basic and clinical research investigating vagus nerve stimulation ...
Citation: Bioelectronic Medicine 2022 8:20 -
Vagus nerve stimulation and inflammation: expanding the scope beyond cytokines
Approximately 20 years ago it was discovered that the vagus nerve regulates pro-inflammatory cytokine levels and inflammation. Subsequent research using several preclinical models revealed that vagus nerve sti...
Citation: Bioelectronic Medicine 2022 8:19 -
A dual tracer [11C]PBR28 and [18F]FDG microPET evaluation of neuroinflammation and brain energy metabolism in murine endotoxemia
Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments....
Citation: Bioelectronic Medicine 2022 8:18 -
Electric field responsive nanotransducers for glioblastoma
Electric field therapies such as Tumor Treating Fields (TTFields) have emerged as a bioelectronic treatment for isocitrate dehydrogenase wild-type and IDH mutant grade 4 astrocytoma Glioblastoma (GBM). TTField...
Citation: Bioelectronic Medicine 2022 8:17 -
High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic pain
Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In precl...
Citation: Bioelectronic Medicine 2022 8:16 -
Bioelectronic multifunctional bone implants: recent trends
The concept of Instrumented Smart Implant emerged as a leading research topic that aims to revolutionize the field of orthopaedic implantology. These implants have been designed incorporating biophysical thera...
Citation: Bioelectronic Medicine 2022 8:15 -
Effect of uniform capacitively coupled electric fields on matrix metabolism of osteoarthritic cartilage
Osteoarthritis (OA) is a common and debilitating condition characterized by degeneration of hyaline cartilage. Currently, there is no treatment for OA that directly targets degradation of cartilage matrix. Cap...
Citation: Bioelectronic Medicine 2022 8:14 -
A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms
Although the coronavirus disease 19 (COVID-19) pandemic has now impacted the world for over two years, the persistent secondary neuropsychiatric effects are still not fully understood. These “long COVID” sympt...
Citation: Bioelectronic Medicine 2022 8:13 -
Delivering transcutaneous auricular neurostimulation (tAN) to improve symptoms associated with opioid withdrawal: results from a prospective clinical trial
As pharmacological treatments are the primary option for opioid use disorder, neuromodulation has recently demonstrated efficacy in managing opioid withdrawal syndrome (OWS). This study investigated the safety...
Citation: Bioelectronic Medicine 2022 8:12 -
Effects of waveform shape and electrode material on KiloHertz frequency alternating current block of mammalian peripheral nerve
KiloHertz frequency alternating current waveforms produce conduction block in peripheral nerves. It is not clearly known how the waveform shape affects block outcomes, and if waveform effects are frequency dep...
Citation: Bioelectronic Medicine 2022 8:11 -
Threshold adjusted vagus nerve stimulation after asphyxial cardiac arrest results in neuroprotection and improved survival
Vagus nerve stimulation (VNS) has shown therapeutic potential in a variety of different diseases with many ongoing clinical trials. The role of VNS in reducing ischemic injury in the brain requires further eva...
Citation: Bioelectronic Medicine 2022 8:10 -
Strategies for precision vagus neuromodulation
The vagus nerve is involved in the autonomic regulation of physiological homeostasis, through vast innervation of cervical, thoracic and abdominal visceral organs. Stimulation of the vagus with bioelectronic d...
Citation: Bioelectronic Medicine 2022 8:9 -
Sex-specific differences in the efficacy of traditional low frequency versus high frequency spinal cord stimulation for chronic pain
Spinal cord stimulation (SCS), an FDA-approved therapy for chronic pain, uses paresthesia (low frequency SCS (LF-SCS)) or paresthesia-free (such as high-frequency SCS (HF-SCS)) systems, providing analgesia thr...
Citation: Bioelectronic Medicine 2022 8:8 -
Anatomical differences in nociceptor neurons sensitivity
Dorsal Root Ganglia (DRG) neurons are derived from the neural crest and mainly innervate the skin, while Jugular Nodose Complex (JNC) neurons originate from the placode and innervate internal organs. These gan...
Citation: Bioelectronic Medicine 2022 8:7 -
Electrical neurostimulation in glaucoma with progressive vision loss
The retrospective study provides real-world evidence for long-term clinical efficacy of electrical optic nerve stimulation (ONS) in glaucoma with progressive vision loss.
Citation: Bioelectronic Medicine 2022 8:6 -
Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
Overactive bladder (OAB) affects 12 to 30% of the world’s population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social i...
Citation: Bioelectronic Medicine 2022 8:5 -
The impact of closed-loop intracortical stimulation on neural activity in brain-injured, anesthetized animals
Acquired brain injuries, such as stroke, are a major cause of long-term disability worldwide. Intracortical microstimulation (ICMS) can be used successfully to assist in guiding appropriate connections to rest...
Citation: Bioelectronic Medicine 2022 8:4 -
Coarse-graining and the Haar wavelet transform for multiscale analysis
Multiscale entropy (MSE) has become increasingly common as a quantitative tool for analysis of physiological signals. The MSE computation involves first decomposing a signal into multiple sub-signal ‘scales’ u...
Citation: Bioelectronic Medicine 2022 8:3 -
Focused ultrasound neuromodulation on a multiwell MEA
Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation methods will significantly enhance the application rang...
Citation: Bioelectronic Medicine 2022 8:2 -
Transcutaneous auricular vagus nerve stimulation (taVNS) for the treatment of pediatric nephrotic syndrome: a pilot study
Children with frequently relapsing nephrotic syndrome (FRNS) and steroid resistant nephrotic syndrome (SRNS) are exposed to immunosuppressant medications with adverse side effects and variable efficacy. Transc...
Citation: Bioelectronic Medicine 2022 8:1 -
Robotic Kinematic measures of the arm in chronic Stroke: part 2 – strong correlation with clinical outcome measures
A detailed sensorimotor evaluation is essential in planning effective, individualized therapy post-stroke. Robotic kinematic assay may offer better accuracy and resolution to understand stroke recovery. Here w...
Citation: Bioelectronic Medicine 2021 7:21 -
Robotic Kinematic measures of the arm in chronic Stroke: part 1 – Motor Recovery patterns from tDCS preceding intensive training
Effectiveness of robotic therapy and transcranial direct current stimulation is conventionally assessed with clinical measures. Robotic metrics may be more objective and sensitive for measuring the efficacy of...
Citation: Bioelectronic Medicine 2021 7:20 -
Injectable wireless microdevices: challenges and opportunities
In the past three decades, we have witnessed unprecedented progress in wireless implantable medical devices that can monitor physiological parameters and interface with the nervous system. These devices are be...
Citation: Bioelectronic Medicine 2021 7:19 -
Correction to: Electrically-evoked vagus nerve recordings using transmural endoscopy in a swine model
Citation: Bioelectronic Medicine 2021 7:18 -
Framework for automated sorting of neural spikes from Neuralynx-acquired tetrode recordings in freely-moving mice
Extracellular recording represents a crucial electrophysiological technique in neuroscience for studying the activity of single neurons and neuronal populations. The electrodes capture voltage traces that, wit...
Citation: Bioelectronic Medicine 2021 7:17 -
Motor improvements enabled by spinal cord stimulation combined with physical training after spinal cord injury: review of experimental evidence in animals and humans
Electrical spinal cord stimulation (SCS) has been gaining momentum as a potential therapy for motor paralysis in consequence of spinal cord injury (SCI). Specifically, recent studies combining SCS with activit...
Citation: Bioelectronic Medicine 2021 7:16 -
Using multielectrode arrays to investigate neurodegenerative effects of the amyloid-beta peptide
Multielectrode arrays are widely used to analyze the effects of potentially toxic compounds, as well as to evaluate neuroprotective agents upon the activity of neural networks in short- and long-term cultures....
Citation: Bioelectronic Medicine 2021 7:15 -
Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications
Almost 100 years ago experiments involving electrically stimulating and recording from the brain and the body launched new discoveries and debates on how electricity, movement, and thoughts are related. Decade...
Citation: Bioelectronic Medicine 2021 7:14 -
A method to quantify autonomic nervous system function in healthy, able-bodied individuals
The autonomic nervous system (ANS) maintains physiological homeostasis in various organ systems via parasympathetic and sympathetic branches. ANS function is altered in common diffuse and focal conditions and ...
Citation: Bioelectronic Medicine 2021 7:13 -
Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography
Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical comp...
Citation: Bioelectronic Medicine 2021 7:12 -
Low frequency conduction block: a promising new technique to advance bioelectronic medicines
Nerve conduction block is an appealing way to selective target the nervous system for treating pathological conditions. Several modalities were described in the past, with the kilohertz frequency stimulation g...
Citation: Bioelectronic Medicine 2021 7:11 -
Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine
Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of to...
Citation: Bioelectronic Medicine 2021 7:10 -
In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block
This paper describes a method to reversibly block nerve conduction through direct application of a 1 Hz sinusoidal current waveform delivered through a bipolar nerve cuff electrode. This low frequency alternat...
Citation: Bioelectronic Medicine 2021 7:9 -
Overview of therapeutic applications of non-invasive vagus nerve stimulation: a motivation for novel treatments for systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disorder that commonly affects the skin, joints, kidneys, and central nervous system. Although great progress has been made over the years, p...
Citation: Bioelectronic Medicine 2021 7:8 -
The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future
There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit “Technology targeting m...
Citation: Bioelectronic Medicine 2021 7:7 -
Progress and challenges of implantable neural interfaces based on nature-derived materials
Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-mot...
Citation: Bioelectronic Medicine 2021 7:6 -
How artificial intelligence can help us ‘Choose Wisely’
The overuse of low value medical tests and treatments drives costs and patient harm. Efforts to address overuse, such as Choosing Wisely campaigns, typically rely on passive implementation strategies- a form o...
Citation: Bioelectronic Medicine 2021 7:5 -
Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders
Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the ...
Citation: Bioelectronic Medicine 2021 7:4 -
Effect of defibrillation on the performance of an implantable vagus nerve stimulation system
Vagus Nerve Stimulation (VNS) delivers Autonomic Regulation Therapy (ART) for heart failure (HF), and has been associated with improvement in cardiac function and heart failure symptoms. VNS is delivered using...
Citation: Bioelectronic Medicine 2021 7:3 -
Changing the tune using bioelectronics
The desire to harness electricity for improving human health dates back at least two millennia. As electrical signals form the basis of communication within our nervous system, the ability to monitor, control,...
Citation: Bioelectronic Medicine 2021 7:2 -
Cut wires: The Electrophysiology of Regenerated Tissue
When nerves are damaged by trauma or disease, they are still capable of firing off electrical command signals that originate from the brain. Furthermore, those damaged nerves have an innate ability to partiall...
Citation: Bioelectronic Medicine 2021 7:1 -
Abstracts from the Fourth Bioelectronic Medicine Summit: Technology Targeting Molecular Mechanisms
Citation: Bioelectronic Medicine 2020 6(Suppl 1):25 -
Immunity and the carotid body: implications for metabolic diseases
Neuro-immune communication has gained enormous interest in recent years due to increasing knowledge of the way in which the brain coordinates functional alterations in inflammatory and autoimmune responses, an...
Citation: Bioelectronic Medicine 2020 6:24 -
Recent progress on peripheral neural interface technology towards bioelectronic medicine
Modulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate exten...
Citation: Bioelectronic Medicine 2020 6:23 -
Autonomic balance determines the severity of COVID-19 courses
COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failu...
Citation: Bioelectronic Medicine 2020 6:22
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