From: Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action
Analgesia-Response To: | |||||
---|---|---|---|---|---|
Neurotransmitter | Receptor Subtype | P-SCS | B-SCS | HF-SCS | DRG-S |
5-HT | 5-HT1: 5-HT2: 5-HT3: 5-HT4: 5-HT6: 5-HT7: | ↔ (Song et al., 2011) ↑ (Barchini et al., 2012) ↑ (Song et al., 2011; Barchini et al., 2012) ↑↑ (Song et al., 2011) ↑ (Song et al., 2011) ↔ (Song et al., 2011) ↔ (Song et al., 2011) | |||
GABA | GABAA: GABAB: | ↑ (Duggan & Foong, 1985; Song et al., 2011; Barchini et al., 2012) ↔ (Cui et al., 1996) ↑↑ (Song et al., 2009; Song et al., 2011; Cui et al., 1996; Barchini et al., 2012) | |||
NE | α1 adrenergic: α2 adrenergic: β1 adrenergic: β2 adrenergic: | ↑ (Barchini et al., 2012) ↑↑ (Barchini et al., 2012; Schechtmann et al., 2004) ↑ (Barchini et al., 2012) ↑ (Barchini et al., 2012) | |||
Dopamine | D2 D3 | ↑ (Barchini et al., 2012) ↑ (Barchini et al., 2012) | |||
ACh | M1 mAChR: M2 mAChR: M3 mAChR: M4 mAChR: nAChR: | ↑ (Schechtmann et al., 2008) ↑ (Schechtmann et al., 2008; Song et al., 2008) ↔ (Schechtmann et al., 2008) ↑↑ (Schechtmann et al., 2008; Song et al., 2008) ↔ (Song et al., 2009) ↔ (Schechtmann et al., 2008) |