Fig. 3

Brain regions with overlapping significantly decreased [¹¹C]PBR28 and [¹⁸F]FDG uptake during endotoxemia. A Simultaneous (dual tracer) uptake decreases in primary and somatosensory motor cortices in LPS administered (n = 6) vs saline administered (n = 6) mice. Dual tracer decreases in metabolism and TSPO binding shown with SPM cluster overlaid onto MRI atlas for visualization (color bar represents t-value height, cutoff threshold T = 2.85). B Individual [¹⁸F]FDG and [¹¹C]PBR28 decreases in primary and somatosensory motor cortices were subjected to post-hoc analysis in the same groups (saline, n = 6 and LPS, n = 6) of mice. **P = 0.002. See Methods for details