Fig. 10
From: Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles
Model perturbations cause the model response to deviate from in vivo data. A Diagram of the computational model of the connection of the cervical vagus nerve (CVN) to the sinoatrial node (SAN) of the heart without the intrinsic cardiac nervous system (ICNS) (Fig. 7A). Stimulation pulses (VNS) cause release of acetylcholine (ACh) to the SAN cells. B Normalized heart rate (HRnorm) response to VNS for in vivo data at bradycardia threshold (solid line), original model with ICNS (dashed line), and model with no ICNS (dot-dashed line) for constant frequency stimulation (i) and burst patterns with intra-burst frequency of 100 Hz (ii). Data presented as mean ± standard error, #difference between modeled HRnorm and measured HRnorm exceeded one standard deviation of in vivo data, n = 8-10 per parameter set for in vivo data, n = 10 runs per parameter set for computational models