Fig. 2

In vivo responses to constant frequency stimulation (intra-burst frequency (Hz) equals mean pulse rate (pulses/s)) of the mouse right cervical vagus at amplitudes of 0.8xBCT (green), 1.0xBCT (blue), and 1.2xBCT (orange). A Heart rate normalized to pre-stimulation baseline (HRnorm). B EMG normalized to response from stimulation at 1.0xBCT, 20 Hz (EMGnorm). C Effect score combining both heart rate and muscle responses normalized to response from stimulation at 1.0xBCT, 20 Hz. Data are presented as mean ± standard error with individual animals as light lines, n = 9-10/parameter set. The standard errors at 20 Hz for 1.0xBCT are 0 because those data points were used for normalization. *p < 0.05 in Tukey post-hoc test, comparing to mean responses to stimulation at 1.0xBCT, 20 Hz