Nicotine
|
TNBS
|
Rat
|
Improves macroscopic colon score, MPO activity, histology.
|
(43)
|
Nicotine
|
TNBS
|
Rat
|
Improves clinical score, macroscopic colon score, MPO activity, histology, colonic tissue LTB4 and TNF levels.
|
(49)
|
Nicotine
|
IL-10 knockout
|
Mouse
|
Improves clinical score and histology in colon; worsens jejunal histology.
|
(50)
|
Neostigmine
|
DNBS
|
Rat
|
Improves clinical score, macroscopic colon score, MPO activity, histology.
|
(51)
|
Vagotomy or nicotine
|
DSS
|
Mouse
|
Vagotomy worsens and nicotine improves clinical score, macroscopic colon score, MPO activity, histology, colonic tissue IL-6, SAP.
|
(52)
|
Vagotomy
|
DNBS
|
Mouse
|
Vagotomy worsens clinical score, macroscopic colon score, MPO activity, histology, colonic tissue IL-6 and TNF, SAP
|
(52)
|
nAChR agonist (AN) or antagonist (CHD)
|
TNBS
|
Mouse
|
nAChR antagonist worsens and nAChR agonist improves histological scores, MPO, TNF and NF-κB in lamina propria mononuclear cells.
|
(53)
|
Choline or α7nAchR antagonist (DMI)
|
DSS or DSS with reactivation
|
Mouse
|
Choline decreases macroscopic scores, MPO, CRP IL-6 and IL-1β while α7nAchR antagonist worsens macroscopic scores and blocks therapeutic benefit of antidepressant.
|
(54)
|
α7nAChR knockout ± vagotomy
|
DSS
|
Mouse
|
Knockout and vagotomy worsen MPO, CRP IL-6 and IL-1β; and knockout prevents therapeutic benefit of choline.
|
(54)
|
Vagotomy
|
DSS
|
Mouse
|
Vagotomy worsens clinical and macroscopic scores, MPO activity; increases colonic NF-κB signaling; increases splenic tissue levels of TNF IL-6, MCP-1; and decreases CD4+FoxP+ Treg cells. Effect of vagotomy can be adoptively transferred via CD4+CD25− T cells.
|
(55)
|
α7-nAchR agonist
|
DSS or TNBS
|
Mouse
|
AR-R17779 and GSK 1345038A either are ineffective or worsen disease
|
(44)
|
Nicotine
|
Oxalazone or TNBS
|
Mouse
|
Oxalazone colitis improves; there is no change in TNBS colitis.
|
(56)
|