Figure 6
From: Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes
A model diagram depicting the antigen-restriction reflex. A neuronal pathway distinguishes between novel and immunized antigens, sending a nerve signal through NaV1.8 + ve, TRPV1neg neurons, which is transmuted into a motor signal leading to restriction of antigen flow from lymph node A to lymph node B (e.g., popliteal to sciatic lymph node).