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Articles
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Citation: Bioelectronic Medicine 2021 7:18
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Framework for automated sorting of neural spikes from Neuralynx-acquired tetrode recordings in freely-moving mice
Extracellular recording represents a crucial electrophysiological technique in neuroscience for studying the activity of single neurons and neuronal populations. The electrodes capture voltage traces that, wit...
Citation: Bioelectronic Medicine 2021 7:17 -
Motor improvements enabled by spinal cord stimulation combined with physical training after spinal cord injury: review of experimental evidence in animals and humans
Electrical spinal cord stimulation (SCS) has been gaining momentum as a potential therapy for motor paralysis in consequence of spinal cord injury (SCI). Specifically, recent studies combining SCS with activit...
Citation: Bioelectronic Medicine 2021 7:16 -
Using multielectrode arrays to investigate neurodegenerative effects of the amyloid-beta peptide
Multielectrode arrays are widely used to analyze the effects of potentially toxic compounds, as well as to evaluate neuroprotective agents upon the activity of neural networks in short- and long-term cultures....
Citation: Bioelectronic Medicine 2021 7:15 -
Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications
Almost 100 years ago experiments involving electrically stimulating and recording from the brain and the body launched new discoveries and debates on how electricity, movement, and thoughts are related. Decade...
Citation: Bioelectronic Medicine 2021 7:14 -
A method to quantify autonomic nervous system function in healthy, able-bodied individuals
The autonomic nervous system (ANS) maintains physiological homeostasis in various organ systems via parasympathetic and sympathetic branches. ANS function is altered in common diffuse and focal conditions and ...
Citation: Bioelectronic Medicine 2021 7:13 -
Miniaturized wireless gastric pacing via inductive power transfer with non-invasive monitoring using cutaneous Electrogastrography
Gastroparesis is a debilitating disease that is often refractory to pharmacotherapy. While gastric electrical stimulation has been studied as a potential treatment, current devices are limited by surgical comp...
Citation: Bioelectronic Medicine 2021 7:12 -
Low frequency conduction block: a promising new technique to advance bioelectronic medicines
Nerve conduction block is an appealing way to selective target the nervous system for treating pathological conditions. Several modalities were described in the past, with the kilohertz frequency stimulation g...
Citation: Bioelectronic Medicine 2021 7:11 -
Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine
Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of to...
Citation: Bioelectronic Medicine 2021 7:10 -
In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block
This paper describes a method to reversibly block nerve conduction through direct application of a 1 Hz sinusoidal current waveform delivered through a bipolar nerve cuff electrode. This low frequency alternat...
Citation: Bioelectronic Medicine 2021 7:9 -
Overview of therapeutic applications of non-invasive vagus nerve stimulation: a motivation for novel treatments for systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disorder that commonly affects the skin, joints, kidneys, and central nervous system. Although great progress has been made over the years, p...
Citation: Bioelectronic Medicine 2021 7:8 -
The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future
There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit “Technology targeting m...
Citation: Bioelectronic Medicine 2021 7:7 -
Progress and challenges of implantable neural interfaces based on nature-derived materials
Neural interfaces are bioelectronic devices capable of stimulating a population of neurons or nerve fascicles and recording electrical signals in a specific area. Despite their success in restoring sensory-mot...
Citation: Bioelectronic Medicine 2021 7:6 -
How artificial intelligence can help us ‘Choose Wisely’
The overuse of low value medical tests and treatments drives costs and patient harm. Efforts to address overuse, such as Choosing Wisely campaigns, typically rely on passive implementation strategies- a form o...
Citation: Bioelectronic Medicine 2021 7:5 -
Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders
Brain stimulation technology has become a viable modality of reversible interventions in the effective treatment of many neurological and psychiatric disorders. It is aimed to restore brain dysfunction by the ...
Citation: Bioelectronic Medicine 2021 7:4 -
Effect of defibrillation on the performance of an implantable vagus nerve stimulation system
Vagus Nerve Stimulation (VNS) delivers Autonomic Regulation Therapy (ART) for heart failure (HF), and has been associated with improvement in cardiac function and heart failure symptoms. VNS is delivered using...
Citation: Bioelectronic Medicine 2021 7:3 -
Changing the tune using bioelectronics
The desire to harness electricity for improving human health dates back at least two millennia. As electrical signals form the basis of communication within our nervous system, the ability to monitor, control,...
Citation: Bioelectronic Medicine 2021 7:2 -
Cut wires: The Electrophysiology of Regenerated Tissue
When nerves are damaged by trauma or disease, they are still capable of firing off electrical command signals that originate from the brain. Furthermore, those damaged nerves have an innate ability to partiall...
Citation: Bioelectronic Medicine 2021 7:1 -
Abstracts from the Fourth Bioelectronic Medicine Summit: Technology Targeting Molecular Mechanisms
Citation: Bioelectronic Medicine 2020 6(Suppl 1):25 -
Immunity and the carotid body: implications for metabolic diseases
Neuro-immune communication has gained enormous interest in recent years due to increasing knowledge of the way in which the brain coordinates functional alterations in inflammatory and autoimmune responses, an...
Citation: Bioelectronic Medicine 2020 6:24 -
Recent progress on peripheral neural interface technology towards bioelectronic medicine
Modulation of the peripheral nervous system (PNS) has a great potential for therapeutic intervention as well as restore bodily functions. Recent interest has focused on autonomic nerves, as they regulate exten...
Citation: Bioelectronic Medicine 2020 6:23 -
Autonomic balance determines the severity of COVID-19 courses
COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failu...
Citation: Bioelectronic Medicine 2020 6:22 -
The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia
Recent evidence demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) propagates in intestinal epithelial cells expressing Angiotensin-Converting Enzyme 2 (ACE2), implying that these c...
Citation: Bioelectronic Medicine 2020 6:20 -
Evidence of Long-range nerve pathways connecting and coordinating activity in secondary lymph organs
Peripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing environmental conditions. Electrical nerve stimulation is commonly used to ac...
Citation: Bioelectronic Medicine 2020 6:21 -
Single arm prospective multicenter case series on the use of burst stimulation to improve pain and motor symptoms in Parkinson’s disease
In this study we analyze new clinical data in the use of spinal cord stimulation (SCS) for the treatment of pain and motor symptoms in patients with Parkinson’s Disease (PD), as both a singular bioelectric the...
Citation: Bioelectronic Medicine 2020 6:18 -
Cortical stimulation in pharmacoresistant focal epilepsies
Pharmacoresistance and adverse drug events designate a considerable group of patients with focal epilepsies that require alternative treatments such as neurosurgical intervention and neurostimulation. Electric...
Citation: Bioelectronic Medicine 2020 6:19 -
Determining grasp selection from arm trajectories via deep learning to enable functional hand movement in tetraplegia
Cervical spinal cord injury severely affects grasping ability of its survivors. Fortunately, many individuals with tetraplegia retain residual arm movements that allow them to reach for objects. We propose a w...
Citation: Bioelectronic Medicine 2020 6:17 -
Ultrasound powered piezoelectric neurostimulation devices: a commentary
Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piez...
Citation: Bioelectronic Medicine 2020 6:16 -
Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the origin of the worldwide COVID-19 pandemic, is characterized by a dramatic cytokine storm in some critical patients with COVID-19. This storm...
Citation: Bioelectronic Medicine 2020 6:15 -
Machine learning to assist clinical decision-making during the COVID-19 pandemic
The number of cases from the coronavirus disease 2019 (COVID-19) global pandemic has overwhelmed existing medical facilities and forced clinicians, patients, and families to make pivotal decisions with limited...
Citation: Bioelectronic Medicine 2020 6:14 -
Parameters matter: modulating cytokines using nerve stimulation
The vagus nerve-based inflammatory reflex regulates inflammation and cytokine release. Recent successful clinical trials using implantable bioelectronic devices to modulate the inflammatory reflex in patients ...
Citation: Bioelectronic Medicine 2020 6:12 -
Ultrasound-driven piezoelectric current activates spinal cord neurocircuits and restores locomotion in rats with spinal cord injury
Neuromodulation via electrical stimulation (ES) is a common technique to treat numerous brain and spinal cord related neurological conditions. In the present study, we examined the efficacy of piezoelectric st...
Citation: Bioelectronic Medicine 2020 6:13 -
A computational outlook on neurostimulation
Efficient identification of effective neurostimulation strategies is critical due to the growing number of clinical applications and the increasing complexity of the corresponding technology. In consequence, i...
Citation: Bioelectronic Medicine 2020 6:10 -
Closed-loop bioelectronic medicine for diabetes management
Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary resea...
Citation: Bioelectronic Medicine 2020 6:11 -
A review of the bioelectronic implications of stimulation of the peripheral nervous system for chronic pain conditions
Peripheral Nerve Stimulation has been used to treat human disease including pain for several decades. Innovation has made it a more viable option for treatment of common chronic pain processes, and interest in...
Citation: Bioelectronic Medicine 2020 6:9 -
Specific vagus nerve stimulation parameters alter serum cytokine levels in the absence of inflammation
Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacio...
Citation: Bioelectronic Medicine 2020 6:8 -
Auricular neural stimulation as a new non-invasive treatment for opioid detoxification
The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are ...
Citation: Bioelectronic Medicine 2020 6:7 -
Correction to: Biomarkers and neuromodulation techniques in substance use disorders
The original version of this article [1], published on 17 February 2020, contained incorrect sentence.
Citation: Bioelectronic Medicine 2020 6:6 -
Spinal cord stimulation in Parkinson’s disease: a review of the preclinical and clinical data and future prospects
Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms incl...
Citation: Bioelectronic Medicine 2020 6:5 -
Biomarkers and neuromodulation techniques in substance use disorders
Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcrania...
Citation: Bioelectronic Medicine 2020 6:4 -
Neural reflex control of vascular inflammation
Atherosclerosis is a multifactorial chronic inflammatory disease that underlies myocardial infarction and stroke. Efficacious treatment for hyperlipidemia and hypertension has significantly reduced morbidity a...
Citation: Bioelectronic Medicine 2020 6:3 -
Building a bioelectronic medicine movement 2019: insights from leaders in industry, academia, and research
In April 2019, a select group of medical, academic, and private-sector leaders in bioelectronic medicine convened in Geneva to discuss the potential for building a cross-disciplinary movement that would advanc...
Citation: Bioelectronic Medicine 2020 6:1 -
Correction to: Prospective trial examining safety and efficacy of microcurrent stimulation for the treatment of sinus pain and congestion
The original version of this article (Goldsobel et al. 2019), published on 20 November 2019, contained incorrect data. In this Correction the affected parts of the article are shown.
Citation: Bioelectronic Medicine 2020 6:2 -
Pulmonary arterial hypertension: the case for a bioelectronic treatment
Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive ...
Citation: Bioelectronic Medicine 2019 5:20 -
Prospective trial examining safety and efficacy of microcurrent stimulation for the treatment of sinus pain and congestion
Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants. Sinonasal inflammation can cause symptoms of nasal c...
Citation: Bioelectronic Medicine 2019 5:18 -
Closed-loop neuromuscular electrical stimulation using feedforward-feedback control and textile electrodes to regulate grasp force in quadriplegia
Transcutaneous neuromuscular electrical stimulation is routinely used in physical rehabilitation and more recently in brain-computer interface applications for restoring movement in paralyzed limbs. Due to var...
Citation: Bioelectronic Medicine 2019 5:19 -
Neuromodulation as a new avenue for resuscitation in hemorrhagic shock
Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid th...
Citation: Bioelectronic Medicine 2019 5:17 -
Homeostatic activity regulation as a mechanism underlying the effect of brain stimulation
Hyperexcitability of the neural network often occurs after brain injuries or degeneration and is a key pathophysiological feature in certain neurological diseases such as epilepsy, neuropathic pain, and tinnit...
Citation: Bioelectronic Medicine 2019 5:16 -
3D-bioprinted tracheal reconstruction: an overview
Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheosto...
Citation: Bioelectronic Medicine 2019 5:15 -
Neural activity regulates autoimmune diseases through the gateway reflex
The brain, spinal cord and retina are protected from blood-borne compounds by the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB) and blood-retina barrier (BRB) respectively, which create a physica...
Citation: Bioelectronic Medicine 2019 5:14
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