Articles

Time Stability and Coherence Analysis of Multiunit, Single-Unit and Local Field Potential Neuronal Signals in Chronically Implanted Brain Electrodes

Introducing neural sensing and decoding to open-loop neurostimulation technologies has the potential to significantly improve the diagnosis and treatment of a wide variety of diseases treated through bioelectr...

Authors: Gaurav Sharma, Nicholas Annetta, David Friedenberg, Tony Blanco, Daphne Vasconcelos, Ammar Shaikhouni, Ali R. Rezai and Chad Bouton

Imagining the Future of Medicine

Christopher J. Czura, PhD, is Vice President of the Feinstein Institute for Medical Research, Executive Publisher of the Feinstein Institute Press’s international, peer-reviewed journals, Molecular Medicine and B...

Authors: Christopher J. Czura

Single-Pulse and Unidirectional Electrical Activation of the Cervical Vagus Nerve Reduces Tumor Necrosis Factor in Endotoxemia

The inflammatory reflex is a neural circuit defined by action potentials transmitted in the vagus nerve that regulate cytokine production in the spleen. Detailed mechanistic studies implicate the vagus nerve, ...

Authors: Peder S. Olofsson, Yaakov A. Levine, April Caravaca, Sangeeta S. Chavan, Valentin A. Pavlov, Michael Faltys and Kevin J. Tracey

Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function

Neuromodulation elicited by electrical stimulation of peripheral or spinal nerves is a U.S. Food and Drug Administered (FDA)-approved therapy for treating disorders of the pelvic viscera, including urinary urg...

Authors: William C. de Groat and Changfeng Tai

Neural Decoding and Applications in Bioelectronic Medicine

Neural decoding is a field involving the use of signal processing and machine learning methods to decode brain activity for various applications including assistive technology for people living with paralysis ...

Authors: Chad Bouton

Implantable Biofuel Cells Operating In Vivo—Potential Power Sources for Bioelectronic Devices

Implantable devices harvesting energy from biological sources and based on electrochemical transducers are currently receiving high attention. The energy collected from the body can be utilized to activate var...

Authors: Evgeny Katz

Neurostimulation of the Cholinergic Antiinflammatory Pathway in Rheumatoid Arthritis and Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) cause significant morbidity and mortality. Despite significant therapeutic advances, the medical need for patients with these disorders remains hi...

Authors: Yaakov A. Levine, Frieda Koopman, Michael Faltys, Ralph Zitnik and Paul-Peter Tak

A Stimulating Concept: Bioelectronic Medicine in Inflammatory Disease

Recent discoveries in neuroscience and immunology have revealed that stimulation of specific neural circuits can ameliorate certain experimental inflammatory diseases. Accumulating evidence on a prototypical r...

Authors: Peder S. Olofsson

The Neural Tourniquet

Bioelectronic medicine aims to understand and harness the beneficial effects of the nervous system and neural circuits to diagnose, treat and prevent disease. For example, targeted electrical stimulation devic...

Authors: Jason R. Fritz and Jared M. Huston

Bioelectronics as a Possible Therapeutic Modality Targeting Sphincteric Dysfunction in Gastrointestinal Disorders

Sphincters in the gastrointestinal tract control the movement of luminal contents in the forward direction and prevent their movement in the backward direction. Defective sphincters are responsible for many of...

Authors: Larry Miller and Anil Vegesna

Graph Theory-Guided Transcranial Magnetic Stimulation in Neurodegenerative Disorders

The emergence of brain imaging techniques has shed light on the underlying mechanisms of brain diseases. Abnormalities found in the diseased brain have often been targeted by transcranial magnetic stimulation ...

Authors: Ji Hyun Ko, Yoon Young Choi and David Eidelberg

Bioelectronic Medicine and the Dawn of Robotic Training to Improve Motor Outcome in Chronic Stroke

Engineers and clinicians have cooperated to produce and test new classes of bioelectronics that have altered motor impairment that occurs after stroke. The rationale that increased intensity of training alters...

Authors: Bruce T. Volpe

Monitoring the Injured Brain

Traumatic brain injury is a serious public health problem in the United States, accounting for nearly 1.7 million injuries and 52,000 deaths annually. The initial brain injury is made worse by secondary events...

Authors: Chunyan Li and Raj K. Narayan

Bioelectronic Medicine—Novel Way to Treat Diseases

Authors: Sangeeta S. Chavan

The Revolutionary Future of Bioelectronic Medicine

Authors: Kevin J. Tracey