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Articles
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Citation: Bioelectronic Medicine 2024 10:18
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The role of spinal cord neuroanatomy in the variances of epidural spinal recordings
Spinal cord stimulation (SCS) has demonstrated multiple benefits in treating chronic pain and other clinical disorders related to sensorimotor dysfunctions. However, the underlying mechanisms are still not ful...
Citation: Bioelectronic Medicine 2024 10:17 -
A multi-channel stimulator with an active electrode array implant for vagal-cardiac neuromodulation studies
Implantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to de...
Citation: Bioelectronic Medicine 2024 10:16 -
Using neural biomarkers to personalize dosing of vagus nerve stimulation
Vagus nerve stimulation (VNS) is an established therapy for treating a variety of chronic diseases, such as epilepsy, depression, obesity, and for stroke rehabilitation. However, lack of precision and side-eff...
Citation: Bioelectronic Medicine 2024 10:15 -
Increase in choroidal thickness after blue light stimulation of the blind spot in young adults
Blue light activates melanopsin, a photopigment that is expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs). The axons of ipRGCs converge on the optic disc, which corresponds to the physi...
Citation: Bioelectronic Medicine 2024 10:13 -
TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens
Key to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune function. Sensory neurons (termed nociceptors) recognize harmful stimuli and...
Citation: Bioelectronic Medicine 2024 10:14 -
Unintentionally intentional: unintended effects of spinal stimulation as a platform for multi-modal neurorehabilitation after spinal cord injury
Electrical stimulation of spinal neurons has emerged as a valuable tool to enhance rehabilitation after spinal cord injury. In separate parameterizations, it has shown promise for improving voluntary movement,...
Citation: Bioelectronic Medicine 2024 10:12 -
Using nonlinear auto-regressive with exogenous input neural network (NNARX) in blood glucose prediction
Predicting of future blood glucose (BG) concentration is important for diabetes control. Many automatic BG monitoring or controlling systems use BG predictors. The accuracy of the prediction for long predictio...
Citation: Bioelectronic Medicine 2024 10:11 -
Evaluation of the EMulate Therapeutics Voyager’s ultra-low radiofrequency energy in murine model of glioblastoma
Glioblastoma (GBM) presents as an aggressive brain cancer, notorious for its recurrence and resistance to conventional treatments. This study aimed to assess the efficacy of the EMulate Therapeutics Voyager®, ...
Citation: Bioelectronic Medicine 2024 10:10 -
A novel neuroimmune modulation system for the treatment of rheumatoid arthritis
The vagus nerve has an anti-inflammatory effect through the inflammatory reflex, which inhibits the release of proinflammatory cytokines by macrophages. Recent pilot clinical trials, using implantable bioelect...
Citation: Bioelectronic Medicine 2024 10:9 -
Clinical safety and feasibility of a novel implantable neuroimmune modulation device for the treatment of rheumatoid arthritis: initial results from the randomized, double-blind, sham-controlled RESET-RA study
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes persistent synovitis, bone damage, and progressive joint destruction. Neuroimmune modulation through electrical stimulation of...
Citation: Bioelectronic Medicine 2024 10:8 -
Harnessing metamaterials for efficient wireless power transfer for implantable medical devices
Wireless power transfer (WPT) within the human body can enable long-lasting medical devices but poses notable challenges, including absorption by biological tissues and weak coupling between the transmitter (T...
Citation: Bioelectronic Medicine 2024 10:7 -
Microfluidic compartmentalization of rat vagal afferent neurons to model gut-brain axis
Vagal afferent neurons represent the key neurosensory branch of the gut-brain axis, which describes the bidirectional communication between the gastrointestinal system and the brain. These neurons are importan...
Citation: Bioelectronic Medicine 2024 10:3 -
A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation
Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in disc...
Citation: Bioelectronic Medicine 2024 10:6 -
Using a standalone ear-EEG device for focal-onset seizure detection
Seizure detection is challenging outside the clinical environment due to the lack of comfortable, reliable, and practical long-term neurophysiological monitoring devices. We developed a novel, discreet, unobst...
Citation: Bioelectronic Medicine 2024 10:4 -
Interfering with sleep apnea
The effects of electromagnetic interference have been hiding in plain sight for millennia and are now being applied to the non-invasive stimulation of deep tissues. In the article by Missey et al., the effect ...
Citation: Bioelectronic Medicine 2024 10:5 -
Evoked compound action potential (ECAP)-controlled closed-loop spinal cord stimulation in an experimental model of neuropathic pain in rats
Preclinical models of spinal cord stimulation (SCS) are lacking objective measurements to inform translationally applicable SCS parameters. The evoked compound action potential (ECAP) represents a measure of d...
Citation: Bioelectronic Medicine 2024 10:2 -
Beyond pediatrics: noninvasive spinal neuromodulation improves motor function in an adult with cerebral palsy
Regaining motor function in individuals with cerebral palsy (CP) has been predominantly studied in children, resulting in an underrepresentation of adults in research efforts. We tested the efficacy of noninva...
Citation: Bioelectronic Medicine 2024 10:1 -
The brain-liver cholinergic anti-inflammatory pathway and viral infections
Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) is the primary source of cholinergic signaling in the body, and partially innervates hepatic functio...
Citation: Bioelectronic Medicine 2023 9:29 -
Trigeminal nerve stimulation: a current state-of-the-art review
Nearly 5 decades ago, the effect of trigeminal nerve stimulation (TNS) on cerebral blood flow was observed for the first time. This implication directly led to further investigations and TNS’ success as a ther...
Citation: Bioelectronic Medicine 2023 9:30 -
Innovative solutions for disease management
The increasing prevalence of chronic diseases is a driver for emerging big data technologies for healthcare including digital platforms for data collection, systems for active patient engagement and education,...
Citation: Bioelectronic Medicine 2023 9:28 -
Non-invasive vagus nerve stimulation: the future of inflammatory bowel disease treatment?
The vagus nerve regulates inflammation and cytokine release through the inflammatory reflex. Recent pilot clinical trials using implantable bioelectronic devices have demonstrated the efficacy of vagus nerve s...
Citation: Bioelectronic Medicine 2023 9:26 -
Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders
Gastrointestinal (GI) disorders, which extend from the esophagus to the anus, are the most common diseases of the GI tract. Among these disorders, pain, encompassing both abdominal and visceral pain, is a pred...
Citation: Bioelectronic Medicine 2023 9:27 -
Rib detection using pitch-catch ultrasound and classification algorithms for a novel ultrasound therapy device
Noninvasive ultrasound (US) has been used therapeutically for decades, with applications in tissue ablation, lithotripsy, and physical therapy. There is increasing evidence that low intensity US stimulation of...
Citation: Bioelectronic Medicine 2023 9:25 -
Gateway reflexes describe novel neuro-immune communications that establish immune cell gateways at specific vessels
Neuroinflammation is an important biological process induced by complex interactions between immune cells and neuronal cells in the central nervous system (CNS). Recent research on the bidirectional communicat...
Citation: Bioelectronic Medicine 2023 9:24 -
Efficacy and safety of transdermal electrical stimulation in patients with nonarteritic anterior ischemic optic neuropathy
No effective treatment for NAION with strong evidence has been established till date. The aim of this investigator-led, prospective, non-randomized, open-label, uncontrolled multi-center exploratory clinical t...
Citation: Bioelectronic Medicine 2023 9:22 -
Transcutaneous auricular vagus nerve stimulation attenuates inflammatory bowel disease in children: a proof-of-concept clinical trial
Vagus nerve stimulation is an investigational anti-inflammatory therapy targeting the nervous system to modulate immune activity. This study evaluated the efficacy and safety of transcutaneous auricular VNS (t...
Citation: Bioelectronic Medicine 2023 9:23 -
The Fifth Bioelectronic Medicine Summit: today’s tools, tomorrow’s therapies
The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment of several neurological and inflammatory disorders. With several BEM therapies being recently approved...
Citation: Bioelectronic Medicine 2023 9:21 -
Wireless agents for brain recording and stimulation modalities
New sensors and modulators that interact wirelessly with medical modalities unlock uncharted avenues for in situ brain recording and stimulation. Ongoing miniaturization, material refinement, and sensitization...
Citation: Bioelectronic Medicine 2023 9:20 -
Impaired parasympathetic function in long-COVID postural orthostatic tachycardia syndrome – a case-control study
Eighty percent of patients infected by SARS-CoV-2 report persistence of one symptom beyond the 4-week convalescent period. Those with orthostatic tachycardia and orthostatic symptoms mimicking postural tachyca...
Citation: Bioelectronic Medicine 2023 9:19 -
Obstructive sleep apnea improves with non-invasive hypoglossal nerve stimulation using temporal interference
Peripheral nerve stimulation is used in both clinical and fundamental research for therapy and exploration. At present, non-invasive peripheral nerve stimulation still lacks the penetration depth to reach deep...
Citation: Bioelectronic Medicine 2023 9:18 -
Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform
The fourth industrial revolution has led to the development and application of health monitoring sensors that are characterized by digitalization and intelligence. These sensors have extensive applications in ...
Citation: Bioelectronic Medicine 2023 9:17 -
Stimulation parameters for directional vagus nerve stimulation
Autonomic nerve stimulation is used as a treatment for a growing number of diseases. We have previously demonstrated that application of efferent vagus nerve stimulation (eVNS) has promising glucose lowering e...
Citation: Bioelectronic Medicine 2023 9:16 -
High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy
The purpose of this study was to evaluate if kilohertz frequency alternating current (KHFAC) stimulation of peripheral nerve could serve as a treatment for lumbar radiculopathy. Prior work shows that KHFAC sti...
Citation: Bioelectronic Medicine 2023 9:15 -
Correction: Neuromodulation for recovery of trunk and sitting functions following spinal cord injury: a comprehensive review of the literature
Citation: Bioelectronic Medicine 2023 9:14 -
Objective wearable measures and subjective questionnaires for predicting response to neurostimulation in people with chronic pain
Neurostimulation is an effective therapy for treating and management of refractory chronic pain. However, the complex nature of pain and infrequent in-clinic visits, determining subject’s long-term response to...
Citation: Bioelectronic Medicine 2023 9:13 -
Remote collection of electrophysiological data with brain wearables: opportunities and challenges
Collection of electroencephalographic (EEG) data provides an opportunity to non-invasively study human brain plasticity, learning and the evolution of various neuropsychiatric disorders. Traditionally, due to ...
Citation: Bioelectronic Medicine 2023 9:12 -
Neuromodulation for recovery of trunk and sitting functions following spinal cord injury: a comprehensive review of the literature
Trunk stability is crucial for people with trunk paralysis resulting from spinal cord injuries (SCI), as it plays a significant role in performing daily life activities and preventing from fall-related acciden...
Citation: Bioelectronic Medicine 2023 9:11 -
3D bioprinting patient-derived induced pluripotent stem cell models of Alzheimer’s disease using a smart bioink
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is becoming increasingly prevalent as our population ages. It is characterized by the buildup of amyloid beta plaques and neurofibrillary tan...
Citation: Bioelectronic Medicine 2023 9:10 -
Vagus nerve stimulation in the non-human primate: implantation methodology, characterization of nerve anatomy, target engagement and experimental applications
Vagus nerve stimulation (VNS) is a FDA approved therapy regularly used to treat a variety of neurological disorders that impact the central nervous system (CNS) including epilepsy and stroke. Putatively, the t...
Citation: Bioelectronic Medicine 2023 9:9 -
Importance of timing optimization for closed-loop applications of vagus nerve stimulation
In recent decades, vagus nerve stimulation (VNS) therapy has become widely used for clinical applications including epilepsy, depression, and enhancing the effects of rehabilitation. However, several questions...
Citation: Bioelectronic Medicine 2023 9:8 -
Brief periods of transcutaneous auricular vagus nerve stimulation improve autonomic balance and alter circulating monocytes and endothelial cells in patients with metabolic syndrome: a pilot study
There is emerging evidence that the nervous system regulates immune and metabolic alterations mediating Metabolic syndrome (MetS) pathogenesis via the vagus nerve. This study evaluated the effects of transcuta...
Citation: Bioelectronic Medicine 2023 9:7 -
Hepatic stellate cell activation markers are regulated by the vagus nerve in systemic inflammation
The liver is an important immunological organ and liver inflammation is part of the pathophysiology of non-alcoholic steatohepatitis, a condition that may promote cirrhosis, liver cancer, liver failure, and ca...
Citation: Bioelectronic Medicine 2023 9:6 -
The Fifth Bioelectronic Medicine Summit Hosted by the Feinstein Institutes for Medical Research (Manhasset, NY) and Columbia Engineering (NY, NY) at The Garden City Hotel, Garden City, NY 11530 on October 11-12th, 2022- Bioelectronic Medicine: Today’s Tools, Tomorrow’s Therapies
Citation: Bioelectronic Medicine 2023 9(Suppl 1):4 -
Characterization and applications of evoked responses during epidural electrical stimulation
Epidural electrical stimulation (EES) of the spinal cord has been FDA approved and used therapeutically for decades. However, there is still not a clear understanding of the local neural substrates and consequ...
Citation: Bioelectronic Medicine 2023 9:5 -
Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles
Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated with therapy for heart failure, but stimulation frequency and amplitude are limited by patient tolerance. An understanding of physiolo...
Citation: Bioelectronic Medicine 2023 9:3 -
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?
Following a SARS-CoV-2 infection, many individuals suffer from post-COVID-19 syndrome. It makes them unable to proceed with common everyday activities due to weakness, memory lapses, pain, dyspnea and other un...
Citation: Bioelectronic Medicine 2023 9:2 -
A radiographic, deep transfer learning framework, adapted to estimate lung opacities from chest x-rays
Chest radiographs (CXRs) are the most widely available radiographic imaging modality used to detect respiratory diseases that result in lung opacities. CXR reports often use non-standardized language that resu...
Citation: Bioelectronic Medicine 2023 9:1 -
Sympathetic innervation of human and porcine spleens: implications for between species variation in function
The vagus nerve affects innate immune responses by activating spleen-projecting sympathetic neurons, which modulate leukocyte function. Recent basic and clinical research investigating vagus nerve stimulation ...
Citation: Bioelectronic Medicine 2022 8:20 -
Vagus nerve stimulation and inflammation: expanding the scope beyond cytokines
Approximately 20 years ago it was discovered that the vagus nerve regulates pro-inflammatory cytokine levels and inflammation. Subsequent research using several preclinical models revealed that vagus nerve sti...
Citation: Bioelectronic Medicine 2022 8:19
Annual Journal Metrics
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Citation Impact 2023
Source Normalized Impact per Paper (SNIP): 0.817
SCImago Journal Rank (SJR): N/A
Speed 2023
Submission to first editorial decision (median days): 3
Submission to acceptance (median days): 41
Usage 2023
Downloads: 332,742
Altmetric mentions: 1,664