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  1. Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary resea...

    Authors: Amparo Güemes Gonzalez, Ralph Etienne-Cummings and Pantelis Georgiou
    Citation: Bioelectronic Medicine 2020 6:11
  2. Peripheral Nerve Stimulation has been used to treat human disease including pain for several decades. Innovation has made it a more viable option for treatment of common chronic pain processes, and interest in...

    Authors: Timothy R. Deer, Ramana Naidu, Natalie Strand, Dawn Sparks, Alaa Abd-Elsayed, Hemant Kalia, Jennifer M. Hah, Pankaj Mehta, Dawood Sayed and Amitabh Gulati
    Citation: Bioelectronic Medicine 2020 6:9
  3. Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacio...

    Authors: Téa Tsaava, Timir Datta-Chaudhuri, Meghan E. Addorisio, Emily Battinelli Masi, Harold A. Silverman, Justin E. Newman, Gavin H. Imperato, Chad Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Eric H. Chang
    Citation: Bioelectronic Medicine 2020 6:8

    The original article was published in Bioelectronic Medicine 2020 6:12

  4. The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are ...

    Authors: Imran S. Qureshi, Timir Datta-Chaudhuri, Kevin J. Tracey, Valentin A. Pavlov and Andrew C. H. Chen
    Citation: Bioelectronic Medicine 2020 6:7
  5. Parkinson’s disease (PD) is a progressive neurodegenerative disease with an incidence of 0.1 to 0.2% over the age of 40 and a prevalence of over 1 million people in North America. The most common symptoms incl...

    Authors: Yi Cai, Rajiv D. Reddy, Vishal Varshney and Krishnan V. Chakravarthy
    Citation: Bioelectronic Medicine 2020 6:5
  6. Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcrania...

    Authors: Bettina Habelt, Mahnaz Arvaneh, Nadine Bernhardt and Ivan Minev
    Citation: Bioelectronic Medicine 2020 6:4

    The Correction to this article has been published in Bioelectronic Medicine 2020 6:6

  7. Atherosclerosis is a multifactorial chronic inflammatory disease that underlies myocardial infarction and stroke. Efficacious treatment for hyperlipidemia and hypertension has significantly reduced morbidity a...

    Authors: A. S. Caravaca, M. Centa, A. L. Gallina, L. Tarnawski and P. S. Olofsson
    Citation: Bioelectronic Medicine 2020 6:3
  8. The original version of this article (Goldsobel et al. 2019), published on 20 November 2019, contained incorrect data. In this Correction the affected parts of the article are shown.

    Authors: Alan B. Goldsobel, Niveditha Prabhakar and Blake T. Gurfein
    Citation: Bioelectronic Medicine 2020 6:2

    The original article was published in Bioelectronic Medicine 2019 5:18

  9. Pulmonary arterial hypertension (PAH) is a rare disease of unknown etiology that progresses to right ventricular failure. It has a complex pathophysiology, which involves an imbalance between vasoconstrictive ...

    Authors: Despοina Ntiloudi, Khaled Qanud, Jacquelyn-Nicole Tomaio, George Giannakoulas, Yousef Al-Abed and Stavros Zanos
    Citation: Bioelectronic Medicine 2019 5:20
  10. Inflammation and swelling of the sinus and nasal mucosa are commonly caused by viral infection, bacterial infection, or exposure to allergens and irritants. Sinonasal inflammation can cause symptoms of nasal c...

    Authors: Alan B. Goldsobel, Niveditha Prabhakar and Blake T. Gurfein
    Citation: Bioelectronic Medicine 2019 5:18

    The Correction to this article has been published in Bioelectronic Medicine 2020 6:2

  11. Transcutaneous neuromuscular electrical stimulation is routinely used in physical rehabilitation and more recently in brain-computer interface applications for restoring movement in paralyzed limbs. Due to var...

    Authors: John Ciancibello, Kevin King, Milad Alizadeh Meghrazi, Subash Padmanaban, Todd Levy, Richard Ramdeo, Malgorzata Straka and Chad Bouton
    Citation: Bioelectronic Medicine 2019 5:19
  12. Hemorrhagic shock (HS), a major cause of early death from trauma, accounts for around 40% of mortality, with 33–56% of these deaths occurring before the patient reaches a medical facility. Intravenous fluid th...

    Authors: Keren Powell, Kevin Shah, Caleb Hao, Yi-Chen Wu, Aashish John, Raj K. Narayan and Chunyan Li
    Citation: Bioelectronic Medicine 2019 5:17
  13. Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheosto...

    Authors: Lidia Frejo and Daniel A. Grande
    Citation: Bioelectronic Medicine 2019 5:15
  14. Neuroimmunomodulation through peripheral nerve activation is an important therapeutic approach to various disorders. Central to this approach is the inflammatory reflex pathway in which the cholinergic anti-in...

    Authors: Shinji Tanaka, Benjamin Hammond, Diane L. Rosin and Mark D. Okusa
    Citation: Bioelectronic Medicine 2019 5:13
  15. Muscle spasticity is a common impediment to motor recovery in patients with chronic stroke. Standard-of-care treatments such as botulinum toxin injections can temporarily relieve muscle stiffness and pain asso...

    Authors: Alexandra Paget-Blanc, Johanna L. Chang, Maira Saul, Regina Lin, Zaghloul Ahmed and Bruce T. Volpe
    Citation: Bioelectronic Medicine 2019 5:11
  16. Glucose is a crucial energy source. In humans, it is the primary sugar for high energy demanding cells in brain, muscle and peripheral neurons. Deviations of blood glucose levels from normal levels for an exte...

    Authors: Emily Battinelli Masi, Todd Levy, Tea Tsaava, Chad E. Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Theodoros P. Zanos
    Citation: Bioelectronic Medicine 2019 5:9
  17. Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers an implantable, non-pharmacologic treatment for patients with intractable chronic pain conditions. Chronic pain is ...

    Authors: Jacob Caylor, Rajiv Reddy, Sopyda Yin, Christina Cui, Mingxiong Huang, Charles Huang, Ramesh Rao, Dewleen G. Baker, Alan Simmons, Dmitri Souza, Samer Narouze, Ricardo Vallejo and Imanuel Lerman
    Citation: Bioelectronic Medicine 2019 5:12
  18. This article [1] has been retracted at the request of the author due to significant overlap with one of his other publications [2] without proper citation. This article is considered redundant. The author agre...

    Authors: Damian Miles Bailey
    Citation: Bioelectronic Medicine 2019 5:7

    The original article was published in Bioelectronic Medicine 2018 4:13

  19. Glutamatergic neurons represent the largest neuronal class in the brain and are responsible for the bulk of excitatory synaptic transmission and plasticity. Abnormalities in glutamatergic neurons are linked to...

    Authors: Eric H. Chang, Samantha T. Carreiro, Stephen A. Frattini and Patricio T. Huerta
    Citation: Bioelectronic Medicine 2019 5:6
  20. Rheumatoid arthritis (RA) is a chronic and debilitating inflammatory disease characterized by extensive joint tissue inflammation. Implantable bioelectronic devices targeting the inflammatory reflex reduce TNF...

    Authors: Meghan E. Addorisio, Gavin H. Imperato, Alex F. de Vos, Steve Forti, Richard S. Goldstein, Valentin A. Pavlov, Tom van der Poll, Huan Yang, Betty Diamond, Kevin J. Tracey and Sangeeta S. Chavan
    Citation: Bioelectronic Medicine 2019 5:4
  21. The loss of motor functions resulting from spinal cord injury can have devastating implications on the quality of one’s life. Functional electrical stimulation has been used to help restore mobility, however, ...

    Authors: Autumn J. Bullard, Samuel R. Nason, Zachary T. Irwin, Chrono S. Nu, Brian Smith, Alex Campean, P. Hunter Peckham, Kevin L. Kilgore, Matthew S. Willsey, Parag G. Patil and Cynthia A. Chestek
    Citation: Bioelectronic Medicine 2019 5:3
  22. The Cleveland Neural Engineering Workshop (NEW) was established as a biennial meeting in 2011, with subsequent meetings taking place in 2013, 2015, and most recently, June 2017. This fourth biennial NEW was ho...

    Authors: Dustin J. Tyler, Christopher J. Czura, Jennifer French, Kip Ludwig, Kevin Otto, Forrest Pape and Cristin Welle
    Citation: Bioelectronic Medicine 2019 5:2
  23. The Cleveland Neural Engineering Workshop (NEW) is a biennial meeting started in 2011 as an “unconference” to bring together leaders in the neural engineering and related fields. Since the first iteration of t...

    Authors: Kim Anderson, Abidemi Ajiboye, Timothy Denison, Jennifer French, Kenneth Gustafson, Kevin Kilgore, Naomi Kleitman, Audrey Kusiak, Brian Litt, Megan Moynahan, Eric Perreault, Douglas Weber, Justin Williams and Dustin Tyler
    Citation: Bioelectronic Medicine 2018 4:15
  24. Rising atmospheric oxygen (O2) levels provided a selective pressure for the evolution of O2-dependent micro-organisms that began with the autotrophic eukaryotes. Since these primordial times, the respiring mammal...

    Authors: Damian Miles Bailey
    Citation: Bioelectronic Medicine 2018 4:13

    The Retraction Note to this article has been published in Bioelectronic Medicine 2019 5:7

  25. Understanding the long-term behavior of intracortically-recorded signals is essential for improving the performance of Brain Computer Interfaces. However, few studies have systematically investigated chronic n...

    Authors: Mingming Zhang, Michael A. Schwemmer, Jordyn E. Ting, Connor E. Majstorovic, David A. Friedenberg, Marcia A. Bockbrader, W. Jerry Mysiw, Ali R. Rezai, Nicholas V. Annetta, Chad E. Bouton, Herbert S. Bresler and Gaurav Sharma
    Citation: Bioelectronic Medicine 2018 4:11
  26. The role of the kidney in glucose homeostasis has gained global interest. Kidneys are innervated by renal nerves, and renal denervation animal models have shown improved glucose regulation. We hypothesized tha...

    Authors: Ahmad A. Jiman, Kavaljit H. Chhabra, Alfor G. Lewis, Paul S. Cederna, Randy J. Seeley, Malcolm J. Low and Tim M. Bruns
    Citation: Bioelectronic Medicine 2018 4:7
  27. Vagus nerve stimulation (VNS) is a promising therapy for many neurologic and psychiatric conditions. However, determining stimulus parameters for individual patients is a major challenge. The traditional metho...

    Authors: Kurt Y. Qing, Kelsey M. Wasilczuk, Matthew P. Ward, Evan H. Phillips, Pavlos P. Vlachos, Craig J. Goergen and Pedro P. Irazoqui
    Citation: Bioelectronic Medicine 2018 4:5
  28. The vagus nerve (VN), the longest nerve of the organism that innervates the gastrointestinal tract, is a mixed nerve composed of 80% of afferent and 20% of efferent fibers. The VN has anti-inflammatory propert...

    Authors: Bruno Bonaz
    Citation: Bioelectronic Medicine 2018 4:4

    The Research article to this article has been published in Bioelectronic Medicine 2023 9:23

  29. The vagus nerve plays an important role in the regulation of organ function, including reflex pathways that regulate immunity and inflammation. Recent studies using genetically modified mice have improved our ...

    Authors: Harold A. Silverman, Andrew Stiegler, Téa Tsaava, Justin Newman, Benjamin E. Steinberg, Emily Battinelli Masi, Sergio Robbiati, Chad Bouton, Patricio T. Huerta, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Bioelectronic Medicine 2018 4:3
  30. Cellular homeostasis is in part controlled by biological generated electrical activity. By interfacing biology with electronic devices this electrical activity can be modulated to actuate cellular behaviour. T...

    Authors: Paola Sanjuan-Alberte, Morgan R. Alexander, Richard J. M. Hague and Frankie J. Rawson
    Citation: Bioelectronic Medicine 2018 4:1
  31. The axons of the sensory, or afferent, vagus nerve transmit action potentials to the central nervous system in response to changes in the body’s metabolic and physiological status. Recent advances in identifyi...

    Authors: Benjamin E. Steinberg, Harold A. Silverman, Sergio Robbiati, Manoj K. Gunasekaran, Téa Tsaava, Emily Battinelli, Andrew Stiegler, Chad E. Bouton, Sangeeta S. Chavan, Kevin J. Tracey and Patricio T. Huerta
    Citation: Bioelectronic Medicine 2016 3:3010007
  32. When pathogens and toxins breech the epithelial barrier, antigens are transported by the lymphatic system to lymph nodes. In previously immunized animals, antigens become trapped in the draining lymph nodes, b...

    Authors: William M. Hanes, Peder S. Olofsson, Sébastien Talbot, Tea Tsaava, Mahendar Ochani, Gavin H. Imperato, Yaakov A. Levine, Jesse Roth, Maud A. Pascal, Simmie L. Foster, Ping Wang, Clifford Woolf, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Bioelectronic Medicine 2016 3:3010018
  33. Vagus nerve stimulation (VNS) has been used since 1997 for treatment of drug-resistant epilepsy. More recently, an off-label use of VNS has been explored in animal models and clinical trials for treatment of a...

    Authors: Harwood Kwan, Luca Garzoni, Hai Lun Liu, Mingju Cao, Andre Desrochers, Gilles Fecteau, Patrick Burns and Martin G. Frasch
    Citation: Bioelectronic Medicine 2016 3:3010001
  34. Hypertension (HTN) affects over 1 billion people in the world, and while most are treated effectively with pharmacological regimens, 10–30% of them do not show a beneficial response. Electrical stimulation of ...

    Authors: Young-tae Kim, Aswini Kanneganti, Caleb Nothnagle, Ryan Landrith, Masaki Mizuno, Muthu B. J. Wijesundara, Scott Smith and Mario I. Romero-Ortega
    Citation: Bioelectronic Medicine 2015 2:2010055
  35. When a peripheral nerve is injured after either trauma or a neurodegenerative disease, motor function and sensory perception are impaired. Repair strategies aim both at reconstructing the damaged nerve and in ...

    Authors: Miyuki Sakuma, Ivan R. Minev, Sandra Gribi, Bhagat Singh, Clifford J. Woolf and Stéphanie P. Lacour
    Citation: Bioelectronic Medicine 2015 2:2010043

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